Cutaneous malignant melanoma. II. The natural history and prognostic factors influencing the development of stage II disease

Donald H. Berdeaux, Frank L. Meyskens, Bruce Parks, Tony Tong, Lois Loescher, Thomas E. Moon

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The survival history of 259 patients with Stage I cutaneous malignant melanoma who were at risk for developing regional nodal metastases (Stage II) were studied. Eighty‐seven of 377 Stage I patients (23%) developed regional nodal metastases (Stage HB) with 40% 5‐year survival. Fifty patients had regional nodal metastases at presentation, with or without a known primary (Stages IIA or lie, respectively), with a 42% 5‐year survival. A step‐down multivariate analysis using the Cox regression model revealed four risk factors as being highly significant for predicting a more favorable survival outcome: (1) thinner Breslow thickness (P = 0.0001), (2) pathologic Stage I disease (P = 0.004), (3) no clinical ulceration (P = 0.0004), and (4) being a woman younger than 50 years of age (P = 0.029). These results are discussed in reference to other series.

Original languageEnglish (US)
Pages (from-to)1430-1436
Number of pages7
JournalCancer
Volume63
Issue number7
DOIs
StatePublished - Apr 1 1989

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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