Cutaneous Melanoma and Obesity in the Agricultural Health Study

Leslie K Dennis, John B. Lowe, Charles F. Lynch, Michael C R Alavanja

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Purpose: To describe the risk of cutaneous melanoma in the Agricultural Health Study (AHS), a cohort of pesticide applicators and their spouses, according to baseline characteristics related to obesity along with sun exposure and sun sensitivity. Methods: The AHS cohort was enrolled in Iowa and North Carolina during 1993-1997 and followed up through 2003 for cancer incidence. We identified 315 cases of cutaneous melanoma, which reduced to 168 incident cases among subjects reporting height, weight, sun sensitivity, and sun exposure information (on the spouse questionnaire or take-home applicator questionnaire; N = 44,086). Unconditional multiple logistic regression models were used to obtain adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: The results were consistent with those of prior studies of melanoma that indicate an association with measures of sun sensitivity. The highest category of body surface area (BSA; OR = 2.6; 95% CI, 1.5-4.4) and body mass index (BMI; OR = 2.5; 95% CI, 1.5-4.3) at age 20 were significantly associated with melanoma. There was some evidence for an association with BSA, but not BMI, at enrollment. Conclusions: Obesity was associated with an increased risk of melanoma, indicating strategies to control obesity may result in risk reduction for melanoma.

Original languageEnglish (US)
Pages (from-to)214-221
Number of pages8
JournalAnnals of Epidemiology
Volume18
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Solar System
Melanoma
Obesity
Skin
Health
Odds Ratio
Confidence Intervals
Spouses
Cohort Studies
Logistic Models
Body Surface Area
Risk Reduction Behavior
Pesticides
Body Mass Index
Weights and Measures
Incidence
Neoplasms
Surveys and Questionnaires

Keywords

  • Agricultural Health Study
  • Body Mass Index
  • Body Surface Area
  • Farmers
  • Lentigo Maligna
  • Melanoma
  • Obesity
  • Sun Sensitivity

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

Cutaneous Melanoma and Obesity in the Agricultural Health Study. / Dennis, Leslie K; Lowe, John B.; Lynch, Charles F.; Alavanja, Michael C R.

In: Annals of Epidemiology, Vol. 18, No. 3, 03.2008, p. 214-221.

Research output: Contribution to journalArticle

Dennis, Leslie K ; Lowe, John B. ; Lynch, Charles F. ; Alavanja, Michael C R. / Cutaneous Melanoma and Obesity in the Agricultural Health Study. In: Annals of Epidemiology. 2008 ; Vol. 18, No. 3. pp. 214-221.
@article{e8c09e6970e2418e8c09f9e06a5599a4,
title = "Cutaneous Melanoma and Obesity in the Agricultural Health Study",
abstract = "Purpose: To describe the risk of cutaneous melanoma in the Agricultural Health Study (AHS), a cohort of pesticide applicators and their spouses, according to baseline characteristics related to obesity along with sun exposure and sun sensitivity. Methods: The AHS cohort was enrolled in Iowa and North Carolina during 1993-1997 and followed up through 2003 for cancer incidence. We identified 315 cases of cutaneous melanoma, which reduced to 168 incident cases among subjects reporting height, weight, sun sensitivity, and sun exposure information (on the spouse questionnaire or take-home applicator questionnaire; N = 44,086). Unconditional multiple logistic regression models were used to obtain adjusted odds ratios (ORs) and 95{\%} confidence intervals (95{\%} CIs). Results: The results were consistent with those of prior studies of melanoma that indicate an association with measures of sun sensitivity. The highest category of body surface area (BSA; OR = 2.6; 95{\%} CI, 1.5-4.4) and body mass index (BMI; OR = 2.5; 95{\%} CI, 1.5-4.3) at age 20 were significantly associated with melanoma. There was some evidence for an association with BSA, but not BMI, at enrollment. Conclusions: Obesity was associated with an increased risk of melanoma, indicating strategies to control obesity may result in risk reduction for melanoma.",
keywords = "Agricultural Health Study, Body Mass Index, Body Surface Area, Farmers, Lentigo Maligna, Melanoma, Obesity, Sun Sensitivity",
author = "Dennis, {Leslie K} and Lowe, {John B.} and Lynch, {Charles F.} and Alavanja, {Michael C R}",
year = "2008",
month = "3",
doi = "10.1016/j.annepidem.2007.09.003",
language = "English (US)",
volume = "18",
pages = "214--221",
journal = "Annals of Epidemiology",
issn = "1047-2797",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Cutaneous Melanoma and Obesity in the Agricultural Health Study

AU - Dennis, Leslie K

AU - Lowe, John B.

AU - Lynch, Charles F.

AU - Alavanja, Michael C R

PY - 2008/3

Y1 - 2008/3

N2 - Purpose: To describe the risk of cutaneous melanoma in the Agricultural Health Study (AHS), a cohort of pesticide applicators and their spouses, according to baseline characteristics related to obesity along with sun exposure and sun sensitivity. Methods: The AHS cohort was enrolled in Iowa and North Carolina during 1993-1997 and followed up through 2003 for cancer incidence. We identified 315 cases of cutaneous melanoma, which reduced to 168 incident cases among subjects reporting height, weight, sun sensitivity, and sun exposure information (on the spouse questionnaire or take-home applicator questionnaire; N = 44,086). Unconditional multiple logistic regression models were used to obtain adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: The results were consistent with those of prior studies of melanoma that indicate an association with measures of sun sensitivity. The highest category of body surface area (BSA; OR = 2.6; 95% CI, 1.5-4.4) and body mass index (BMI; OR = 2.5; 95% CI, 1.5-4.3) at age 20 were significantly associated with melanoma. There was some evidence for an association with BSA, but not BMI, at enrollment. Conclusions: Obesity was associated with an increased risk of melanoma, indicating strategies to control obesity may result in risk reduction for melanoma.

AB - Purpose: To describe the risk of cutaneous melanoma in the Agricultural Health Study (AHS), a cohort of pesticide applicators and their spouses, according to baseline characteristics related to obesity along with sun exposure and sun sensitivity. Methods: The AHS cohort was enrolled in Iowa and North Carolina during 1993-1997 and followed up through 2003 for cancer incidence. We identified 315 cases of cutaneous melanoma, which reduced to 168 incident cases among subjects reporting height, weight, sun sensitivity, and sun exposure information (on the spouse questionnaire or take-home applicator questionnaire; N = 44,086). Unconditional multiple logistic regression models were used to obtain adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: The results were consistent with those of prior studies of melanoma that indicate an association with measures of sun sensitivity. The highest category of body surface area (BSA; OR = 2.6; 95% CI, 1.5-4.4) and body mass index (BMI; OR = 2.5; 95% CI, 1.5-4.3) at age 20 were significantly associated with melanoma. There was some evidence for an association with BSA, but not BMI, at enrollment. Conclusions: Obesity was associated with an increased risk of melanoma, indicating strategies to control obesity may result in risk reduction for melanoma.

KW - Agricultural Health Study

KW - Body Mass Index

KW - Body Surface Area

KW - Farmers

KW - Lentigo Maligna

KW - Melanoma

KW - Obesity

KW - Sun Sensitivity

UR - http://www.scopus.com/inward/record.url?scp=38949191311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38949191311&partnerID=8YFLogxK

U2 - 10.1016/j.annepidem.2007.09.003

DO - 10.1016/j.annepidem.2007.09.003

M3 - Article

C2 - 18280921

AN - SCOPUS:38949191311

VL - 18

SP - 214

EP - 221

JO - Annals of Epidemiology

JF - Annals of Epidemiology

SN - 1047-2797

IS - 3

ER -