Abstract
This study documents the immunohistologic and ultrastructural morphometric features of a case of cutaneous myiasis due to Dermatobia hominis. The mixed host inflammatory response surrounding the larvae included lymphoblasts, eosinophils, activated fibroblasts, mature histiocytes, mast cells, plasma cells, and Langerhans cells, indicating a complex interactive immunologic response to the botfly parasite. Immunotyping revealed that the dominant dermal cells were activated (Ia+) T-helper cells. Although the strikingly elevated T-helper/T-suppressor cell ratio might suggest a monoclonal infiltrate, a mixture of Leu 8+ and Leu8- T-cells indicates both immunoregulatory subsets of T-helper cells as found in a reactive process. Furthermore, our ultrastructural histogram found the lymphoid nuclear shapes were oval with few nuclear invaginations as found in inflammatory infiltrates. As indicated by electron microscopy, there were abundant activated fibroblasts elaborating collagen which may relate to larval containment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 232-239 |
| Number of pages | 8 |
| Journal | American Journal of Dermatopathology |
| Volume | 9 |
| Issue number | 3 |
| State | Published - 1987 |
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ASJC Scopus subject areas
- Dermatology
- Pathology and Forensic Medicine
Cite this
Cutaneous myiasis. Immunohistologic and ultrastructural morphometric features of a human botfly lesion. / Grogan, T. M.; Payne, C. M.; Payne, T. B.; Perry, Catherine S; Cromey, D. W.; Rangel, C.; Richter, L.
In: American Journal of Dermatopathology, Vol. 9, No. 3, 1987, p. 232-239.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cutaneous myiasis. Immunohistologic and ultrastructural morphometric features of a human botfly lesion
AU - Grogan, T. M.
AU - Payne, C. M.
AU - Payne, T. B.
AU - Perry, Catherine S
AU - Cromey, D. W.
AU - Rangel, C.
AU - Richter, L.
PY - 1987
Y1 - 1987
N2 - This study documents the immunohistologic and ultrastructural morphometric features of a case of cutaneous myiasis due to Dermatobia hominis. The mixed host inflammatory response surrounding the larvae included lymphoblasts, eosinophils, activated fibroblasts, mature histiocytes, mast cells, plasma cells, and Langerhans cells, indicating a complex interactive immunologic response to the botfly parasite. Immunotyping revealed that the dominant dermal cells were activated (Ia+) T-helper cells. Although the strikingly elevated T-helper/T-suppressor cell ratio might suggest a monoclonal infiltrate, a mixture of Leu 8+ and Leu8- T-cells indicates both immunoregulatory subsets of T-helper cells as found in a reactive process. Furthermore, our ultrastructural histogram found the lymphoid nuclear shapes were oval with few nuclear invaginations as found in inflammatory infiltrates. As indicated by electron microscopy, there were abundant activated fibroblasts elaborating collagen which may relate to larval containment.
AB - This study documents the immunohistologic and ultrastructural morphometric features of a case of cutaneous myiasis due to Dermatobia hominis. The mixed host inflammatory response surrounding the larvae included lymphoblasts, eosinophils, activated fibroblasts, mature histiocytes, mast cells, plasma cells, and Langerhans cells, indicating a complex interactive immunologic response to the botfly parasite. Immunotyping revealed that the dominant dermal cells were activated (Ia+) T-helper cells. Although the strikingly elevated T-helper/T-suppressor cell ratio might suggest a monoclonal infiltrate, a mixture of Leu 8+ and Leu8- T-cells indicates both immunoregulatory subsets of T-helper cells as found in a reactive process. Furthermore, our ultrastructural histogram found the lymphoid nuclear shapes were oval with few nuclear invaginations as found in inflammatory infiltrates. As indicated by electron microscopy, there were abundant activated fibroblasts elaborating collagen which may relate to larval containment.
UR - http://www.scopus.com/inward/record.url?scp=0023636558&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023636558&partnerID=8YFLogxK
M3 - Article
C2 - 3498374
AN - SCOPUS:0023636558
VL - 9
SP - 232
EP - 239
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
SN - 0193-1091
IS - 3
ER -