Cutaneous myiasis. Immunohistologic and ultrastructural morphometric features of a human botfly lesion

T. M. Grogan, C. M. Payne, T. B. Payne, Catherine S Perry, D. W. Cromey, C. Rangel, L. Richter

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

This study documents the immunohistologic and ultrastructural morphometric features of a case of cutaneous myiasis due to Dermatobia hominis. The mixed host inflammatory response surrounding the larvae included lymphoblasts, eosinophils, activated fibroblasts, mature histiocytes, mast cells, plasma cells, and Langerhans cells, indicating a complex interactive immunologic response to the botfly parasite. Immunotyping revealed that the dominant dermal cells were activated (Ia+) T-helper cells. Although the strikingly elevated T-helper/T-suppressor cell ratio might suggest a monoclonal infiltrate, a mixture of Leu 8+ and Leu8- T-cells indicates both immunoregulatory subsets of T-helper cells as found in a reactive process. Furthermore, our ultrastructural histogram found the lymphoid nuclear shapes were oval with few nuclear invaginations as found in inflammatory infiltrates. As indicated by electron microscopy, there were abundant activated fibroblasts elaborating collagen which may relate to larval containment.

Original languageEnglish (US)
Pages (from-to)232-239
Number of pages8
JournalAmerican Journal of Dermatopathology
Volume9
Issue number3
StatePublished - 1987

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Myiasis
Helper-Inducer T-Lymphocytes
Skin
Fibroblasts
Histiocytes
Langerhans Cells
Plasma Cells
Eosinophils
Mast Cells
Larva
Electron Microscopy
Parasites
Collagen
T-Lymphocytes

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Grogan, T. M., Payne, C. M., Payne, T. B., Perry, C. S., Cromey, D. W., Rangel, C., & Richter, L. (1987). Cutaneous myiasis. Immunohistologic and ultrastructural morphometric features of a human botfly lesion. American Journal of Dermatopathology, 9(3), 232-239.

Cutaneous myiasis. Immunohistologic and ultrastructural morphometric features of a human botfly lesion. / Grogan, T. M.; Payne, C. M.; Payne, T. B.; Perry, Catherine S; Cromey, D. W.; Rangel, C.; Richter, L.

In: American Journal of Dermatopathology, Vol. 9, No. 3, 1987, p. 232-239.

Research output: Contribution to journalArticle

Grogan, TM, Payne, CM, Payne, TB, Perry, CS, Cromey, DW, Rangel, C & Richter, L 1987, 'Cutaneous myiasis. Immunohistologic and ultrastructural morphometric features of a human botfly lesion', American Journal of Dermatopathology, vol. 9, no. 3, pp. 232-239.
Grogan, T. M. ; Payne, C. M. ; Payne, T. B. ; Perry, Catherine S ; Cromey, D. W. ; Rangel, C. ; Richter, L. / Cutaneous myiasis. Immunohistologic and ultrastructural morphometric features of a human botfly lesion. In: American Journal of Dermatopathology. 1987 ; Vol. 9, No. 3. pp. 232-239.
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