Cutaneous ulceration due to contrast extravasation. Experimental assessment of injury and potential antidotes

E. A. Elam, Robert T Dorr, K. E. Lagel, G. D. Pond

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Severe cutaneous ulceration may occur as a result of contrast media extravasation. We established a definitive animal model for assessing the cutaneous toxicity of commonly employed agents and used this model to evaluate possible antidotes to the effects of contrast media extravasation. The contrast agents studied were: meglumine/sodium diatrizoate 76%, meglumine iothalamate 60% and 43%, meglumine/sodium ioxaglate 60%, iohexol 350, and iopamidol 370, in varying volumes and osmolalities. Hypertonic saline (950 and 1900 mOsm/kg) also was injected. Agents were injected intradermally into BALB/c mice. The higher osmolality agents produced dose-dependent skin ulcerations. The lower osmolality agents failed to produce any skin lesions after the same volume doses. Hypertonic saline produced skin toxicity in a dose-dependent fashion similar to hyperosmolar contrast agents. Three antidotes were tested: hjyaluronidase, topical heat, and topical cold. Hyaluronidase significantly reduced skin toxicity when injected immediately following contrast injection. Cold also significantly reduced skin toxicity, while heat caused no improvement.

Original languageEnglish (US)
Pages (from-to)13-16
Number of pages4
JournalInvestigative Radiology
Volume26
Issue number1
DOIs
StatePublished - 1991

Fingerprint

Antidotes
Skin
Wounds and Injuries
Extravasation of Diagnostic and Therapeutic Materials
Ioxaglic Acid
Osmolar Concentration
Diatrizoate Meglumine
Contrast Media
Hot Temperature
Iothalamic Acid
Iopamidol
Iohexol
Diatrizoate
Hyaluronoglucosaminidase
Animal Models
Injections

Keywords

  • contrast media
  • extravasation injury
  • toxicity
  • treatment

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Cutaneous ulceration due to contrast extravasation. Experimental assessment of injury and potential antidotes. / Elam, E. A.; Dorr, Robert T; Lagel, K. E.; Pond, G. D.

In: Investigative Radiology, Vol. 26, No. 1, 1991, p. 13-16.

Research output: Contribution to journalArticle

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