Cutting Edge: Cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells

Gabriel J. Sandoval, Daniel B. Graham, Deepta Bhattacharya, Barry P. Sleckman, Ramnik J. Xavier, Wojciech Swat

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

During early stages of B-lineage differentiation in bone marrow, signals emanating from IL-7R and pre-BCR are thought to synergistically induce proliferative expansion of progenitor cells. Paradoxically, loss of pre- BCR-signaling components is associated with leukemia in both mice and humans. Exactly how progenitor B cells perform the task of balancing proliferative burst dependent on IL-7 with the termination of IL-7 signals and the initiation of L chain gene rearrangement remains to be elucidated. In this article, we provide genetic and functional evidence that the cessation of the IL-7 response of pre-B cells is controlled via a cellautonomous mechanism that operates at a discrete developmental transition inside Fraction C9 (large pre- BII) marked by transient expression of c-Myc. Our data indicate that pre-BCR cooperates with IL-7R in expanding the pre-B cell pool, but it is also critical to control the differentiation program shutting off the c-Myc gene in large pre-B cells.

Original languageEnglish (US)
Pages (from-to)2485-2489
Number of pages5
JournalJournal of Immunology
Volume190
Issue number6
DOIs
StatePublished - Mar 15 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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