Cutting edge: The aging immune system reveals the biological impact of direct antigen presentation on CD8 T cell responses

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The vertebrate immune system uses multiple, sometimes redundant, mechanisms to contain pathogenic microorganisms that are always evolving to evade host defenses. Thus, the cowpox virus (CPXV) uses genes encoding CPXV12 and CPXV203 to prevent direct MHC class I presentation of viral peptides by infected cells. However, CD8 T cells are effectively primed against CPXV by cross-presentation of viral Ags in young mice. Old mice accumulate defects in both CD8 T cell activation and cross-presentation. Using a double-deletion mutant (?12?203) of CPXV, we show that direct priming of CD8 T cells in old mice yields superior recall responses, establishing a key contribution of this mechanism to host antipoxvirus responses and enhancing our fundamental understanding of how viral manipulation of direct presentation impacts pathogenesis. This also provides a proof of principle that suboptimal CD8 T cell in old organisms can be optimized by manipulating Ag presentation, with implications for vaccine design.

Original languageEnglish (US)
Pages (from-to)403-407
Number of pages5
JournalJournal of Immunology
Volume199
Issue number2
DOIs
StatePublished - Jul 15 2017

ASJC Scopus subject areas

  • Immunology

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