Cycloartane- And Lanostane-Type Triterpenoids from the Resin of Parthenium argentatum AZ-2, a Byproduct of Guayule Rubber Production

Ya Ming Xu, Chandrashekhar Madasu, Manping X. Liu, E. M.Kithsiri Wijeratne, David Dierig, Bob White, István Molnár, A. A.Leslie Gunatilaka

Research output: Contribution to journalArticlepeer-review

Abstract

A total of 12 new cycloartane- and lanostane-type triterpenoids including 16-deoxyargentatin A (1), 16-deoxyisoargentatin A (2), 7-oxoisoargentatin A (3), 24-epi-argentatin H (4), 24-O-p-anisoylargentatin C (5), 24-O-trans-cinnamoylargentatin C (6), 16-dehydroargentatin C (7), 16,17(20)-didehydroargentatin C (8), isoargentatin C (9), isoargentatin H (10), 3-epi-quisquagenin (11), and isoquisquagenin (12) together with 10 known triterpenoids (13-22) were isolated from the resin of Parthenium argentatum AZ-2 obtained as a byproduct of Bridgestone guayule rubber production. The structures of new triterpenoids 1-12 and argentatin H (13), which has previously been characterized as its diacetate (23), were elucidated by extensive analysis of their spectroscopic data and chemical conversions, and the known compounds 14-22 were identified by comparison of their spectroscopic data with those reported. Of these, 13, 14, and 18 exhibited weak cytotoxic activity for several cancer cell lines.

Original languageEnglish (US)
Pages (from-to)15486-15498
Number of pages13
JournalACS Omega
Volume6
Issue number23
DOIs
StatePublished - Jun 15 2021

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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