Cyclododecane and cyclotridecane complexes with cobalt as potent histidine chelators: A theoretical study

Bartosz Trzaskowski, Roberto Guzman, Ludwik Adamowicz

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Density functional theory calculations have been employed to study the interaction between cyclododecane and cyclotridecane derivatives complexing cobalt and interacting with histidine. The results suggest that some of these derivatives have high molecular affinities toward histidine, higher than in the commonly used iminodiacetate-cobalt system. Those derivatives may become new, potent chelators for use in the immobilized-metal-ion-affinity chromatography to immobilize and/or purify peptides and proteins.

Original languageEnglish (US)
Pages (from-to)2477-2481
Number of pages5
JournalPolyhedron
Volume26
Issue number12
DOIs
StatePublished - Jul 23 2007

Keywords

  • Cyclododecanes
  • Cyclotridecanes
  • DFT
  • IMAC

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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