Cyclospora cayetanensis

Y. R. Ortega, Charles R Sterling, R. H. Gilman

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Cyclospora cayetanensis is a coccidian pathogen in humans. Cyclosporiasis is characterized by mild to severe nausea, anorexia, abdominal cramping, and watery diarrhea. Cyclospora has now been described from patients with protracted diarrheal illness in North, Central and South America, the Caribbean, Africa, Bangladesh, south-east Asia, Australia, England, and eastern Europe, and is characterized by marked seasonality. Routes of transmission are still unknown, although the fecal-oral route, either directly or via water, is probably the major one. A recent outbreak in the USA suggested transmission of Cyclospora by ingestion of contaminated berries. Cyclospora oocysts can be detected by phase contrast microscopy, modified acid-fast staining, autofluorescence, and amplification by the polymerase chain reaction. Oocysts are not sporulated when excreted in the feces, and sporulated oocysts are needed for infection. Each sporulated oocyst contains two sporocysts and each sporocyst contains two sporozoites. Humans seem to be the only host for this parasite. Histopathological examination of jejunal biopsies from infected individuals showed mild to moderate acute inflammation of the lamina propria and surface epithelial disarray. Parasitophorous vacuoles containing sexual and asexual forms of Cycl. cayetanensis were located in the cytoplasm of epithelial cells. Cyclospora infections can be treated succesfully with trimethoprim-sulfamethoxazole.

Original languageEnglish (US)
Pages (from-to)399-418
Number of pages20
JournalAdvances in Parasitology
Volume40
StatePublished - 1998

Fingerprint

Cyclospora
Oocysts
Cyclosporiasis
Phase-Contrast Microscopy
Central America
Eastern Europe
Sporozoites
Bangladesh
Far East
South America
Sulfamethoxazole Drug Combination Trimethoprim
Anorexia
North America
South Africa
Vacuoles
Infection
Feces
England
Nausea
Disease Outbreaks

ASJC Scopus subject areas

  • Parasitology

Cite this

Ortega, Y. R., Sterling, C. R., & Gilman, R. H. (1998). Cyclospora cayetanensis. Advances in Parasitology, 40, 399-418.

Cyclospora cayetanensis. / Ortega, Y. R.; Sterling, Charles R; Gilman, R. H.

In: Advances in Parasitology, Vol. 40, 1998, p. 399-418.

Research output: Contribution to journalArticle

Ortega, YR, Sterling, CR & Gilman, RH 1998, 'Cyclospora cayetanensis', Advances in Parasitology, vol. 40, pp. 399-418.
Ortega YR, Sterling CR, Gilman RH. Cyclospora cayetanensis. Advances in Parasitology. 1998;40:399-418.
Ortega, Y. R. ; Sterling, Charles R ; Gilman, R. H. / Cyclospora cayetanensis. In: Advances in Parasitology. 1998 ; Vol. 40. pp. 399-418.
@article{123121a0c77248a1b3534a79189a4e2e,
title = "Cyclospora cayetanensis",
abstract = "Cyclospora cayetanensis is a coccidian pathogen in humans. Cyclosporiasis is characterized by mild to severe nausea, anorexia, abdominal cramping, and watery diarrhea. Cyclospora has now been described from patients with protracted diarrheal illness in North, Central and South America, the Caribbean, Africa, Bangladesh, south-east Asia, Australia, England, and eastern Europe, and is characterized by marked seasonality. Routes of transmission are still unknown, although the fecal-oral route, either directly or via water, is probably the major one. A recent outbreak in the USA suggested transmission of Cyclospora by ingestion of contaminated berries. Cyclospora oocysts can be detected by phase contrast microscopy, modified acid-fast staining, autofluorescence, and amplification by the polymerase chain reaction. Oocysts are not sporulated when excreted in the feces, and sporulated oocysts are needed for infection. Each sporulated oocyst contains two sporocysts and each sporocyst contains two sporozoites. Humans seem to be the only host for this parasite. Histopathological examination of jejunal biopsies from infected individuals showed mild to moderate acute inflammation of the lamina propria and surface epithelial disarray. Parasitophorous vacuoles containing sexual and asexual forms of Cycl. cayetanensis were located in the cytoplasm of epithelial cells. Cyclospora infections can be treated succesfully with trimethoprim-sulfamethoxazole.",
author = "Ortega, {Y. R.} and Sterling, {Charles R} and Gilman, {R. H.}",
year = "1998",
language = "English (US)",
volume = "40",
pages = "399--418",
journal = "Advances in Parasitology",
issn = "0065-308X",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Cyclospora cayetanensis

AU - Ortega, Y. R.

AU - Sterling, Charles R

AU - Gilman, R. H.

PY - 1998

Y1 - 1998

N2 - Cyclospora cayetanensis is a coccidian pathogen in humans. Cyclosporiasis is characterized by mild to severe nausea, anorexia, abdominal cramping, and watery diarrhea. Cyclospora has now been described from patients with protracted diarrheal illness in North, Central and South America, the Caribbean, Africa, Bangladesh, south-east Asia, Australia, England, and eastern Europe, and is characterized by marked seasonality. Routes of transmission are still unknown, although the fecal-oral route, either directly or via water, is probably the major one. A recent outbreak in the USA suggested transmission of Cyclospora by ingestion of contaminated berries. Cyclospora oocysts can be detected by phase contrast microscopy, modified acid-fast staining, autofluorescence, and amplification by the polymerase chain reaction. Oocysts are not sporulated when excreted in the feces, and sporulated oocysts are needed for infection. Each sporulated oocyst contains two sporocysts and each sporocyst contains two sporozoites. Humans seem to be the only host for this parasite. Histopathological examination of jejunal biopsies from infected individuals showed mild to moderate acute inflammation of the lamina propria and surface epithelial disarray. Parasitophorous vacuoles containing sexual and asexual forms of Cycl. cayetanensis were located in the cytoplasm of epithelial cells. Cyclospora infections can be treated succesfully with trimethoprim-sulfamethoxazole.

AB - Cyclospora cayetanensis is a coccidian pathogen in humans. Cyclosporiasis is characterized by mild to severe nausea, anorexia, abdominal cramping, and watery diarrhea. Cyclospora has now been described from patients with protracted diarrheal illness in North, Central and South America, the Caribbean, Africa, Bangladesh, south-east Asia, Australia, England, and eastern Europe, and is characterized by marked seasonality. Routes of transmission are still unknown, although the fecal-oral route, either directly or via water, is probably the major one. A recent outbreak in the USA suggested transmission of Cyclospora by ingestion of contaminated berries. Cyclospora oocysts can be detected by phase contrast microscopy, modified acid-fast staining, autofluorescence, and amplification by the polymerase chain reaction. Oocysts are not sporulated when excreted in the feces, and sporulated oocysts are needed for infection. Each sporulated oocyst contains two sporocysts and each sporocyst contains two sporozoites. Humans seem to be the only host for this parasite. Histopathological examination of jejunal biopsies from infected individuals showed mild to moderate acute inflammation of the lamina propria and surface epithelial disarray. Parasitophorous vacuoles containing sexual and asexual forms of Cycl. cayetanensis were located in the cytoplasm of epithelial cells. Cyclospora infections can be treated succesfully with trimethoprim-sulfamethoxazole.

UR - http://www.scopus.com/inward/record.url?scp=0032471411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032471411&partnerID=8YFLogxK

M3 - Article

C2 - 9554080

AN - SCOPUS:0032471411

VL - 40

SP - 399

EP - 418

JO - Advances in Parasitology

JF - Advances in Parasitology

SN - 0065-308X

ER -