Cyclosporine A modulation of Ca++ activated K+ channels in cardiac sensory afferent neurons

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Whole-cell and single channel recordings were used to characterize the effects of the immunosuppressant cyclosporine A (CsA) on cardiac sensory neurons (CSN) of the nodose ganglia. Application of 10 nM CsA resulted in a 29.1% decrease in CSN input resistance and an average -8 ± 3 mV hyperpolarization of membrane potential. Application of 10 nM CsA had no effect on evoke Ca++ currents but increased evoked K+ currents by 158.9 ± 24%. Application of 10 nM CsA significantly increased the open probability of KCa channels by 183 ± 9%. These results suggest that application of CsA results in the activation of KCa channels in cardiac sensory neurons and this effect may contribute to the cellular mechanisms underlying CsA modulation of vagal afferent neurons.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalBrain Research
Volume786
Issue number1-2
DOIs
StatePublished - Mar 9 1998
Externally publishedYes

Keywords

  • Calcium channels
  • Cyclosporine
  • Patch-clamp
  • Potassium channels
  • Vagal afferents

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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