CYP17 promoter variant associated with prostate cancer aggressiveness in African Americans

Rick A. Kittles, Ramesh K. Panguluri, Weidong Chen, Aisha Massac, Georgia M. Dunston, Rick A. Kittles, Chiledum Ahaghotu, Aaron Jackson, Rick A. Kittles, Flora Ukoli, Lucile Adams-Campbell, Georgia M. Dunston, William Isaacs

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Androgens play an important role in the etiology of prostate cancer. The CYP17 gene encodes the cytochrome P450c17α enzyme, which is the rate-limiting enzyme in androgen biosynthesis. A T to C polymorphism in the 5′ promoter region has recently been associated with prostate cancer. However, contradictory data exists concerning the risk allele. To investigate further the involvement of the CYP17 variant with prostate cancer, we typed the polymorphism in three different populations and evaluated its association with prostate cancer and clinical presentation in African Americans. We genotyped the CYP17 polymorphism in Nigerian (n = 56), European-American (n = 74), and African-American (n = 111) healthy male volunteers, along with African-American men affected with prostate cancer (n = 71), using pyrosequencing. Genotype and allele frequencies did not differ significantly across the different control populations. African-American men with the CC CYP17 genotype had an increased risk of prostate cancer (odds ratio, 2.8; 95% confidence interval, 1.0-7.4) compared with those with the TT genotype. A similar trend was observed between the homozygous variant genotype in African-American prostate cancer patients and clinical presentation. The CC genotype was significantly associated with higher grade and stage of prostate cancer (odds ratio, 7.1; 95% confidence interval, 1.4-36, 1). The risk did not differ significantly by family history or age. Our results suggest that the C allele of the CYP17 polymorphism is significantly associated with increased prostate cancer risk and clinically advanced disease in African Americans.

Original languageEnglish (US)
Pages (from-to)943-947
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume10
Issue number9
StatePublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Fingerprint Dive into the research topics of 'CYP17 promoter variant associated with prostate cancer aggressiveness in African Americans'. Together they form a unique fingerprint.

  • Cite this

    Kittles, R. A., Panguluri, R. K., Chen, W., Massac, A., Dunston, G. M., Kittles, R. A., Ahaghotu, C., Jackson, A., Kittles, R. A., Ukoli, F., Adams-Campbell, L., Dunston, G. M., & Isaacs, W. (2001). CYP17 promoter variant associated with prostate cancer aggressiveness in African Americans. Cancer Epidemiology Biomarkers and Prevention, 10(9), 943-947.