Cysteine-string protein's neuroprotective role

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Abstract

Cysteine-string protein (CSP), a member of the DnaJ/Hsp40 family of cochaperones, is critical for maintaining neurotransmitter release and preventing neurodegeneration. CSP likely forms a chaperone complex on synaptic vesicles together with the 70-kDa heat shock cognate (Hsc70) and the small glutamine-rich tetratricopeptide repeat (TPR)-containing protein (SGT) that may control or protect the assembly and activity of SNARE proteins and various other protein substrates. Here, the author summarizes studies that elucidated CSP's neuroprotective role.

Original languageEnglish (US)
Pages (from-to)120-132
Number of pages13
JournalJournal of Neurogenetics
Volume24
Issue number3
DOIs
Publication statusPublished - Sep 2010

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Keywords

  • cysteine-string protein
  • neurodegeneration
  • neurotransmitter release
  • synaptic vesicle

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Genetics

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