Cysteine-string protein's neuroprotective role

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Cysteine-string protein (CSP), a member of the DnaJ/Hsp40 family of cochaperones, is critical for maintaining neurotransmitter release and preventing neurodegeneration. CSP likely forms a chaperone complex on synaptic vesicles together with the 70-kDa heat shock cognate (Hsc70) and the small glutamine-rich tetratricopeptide repeat (TPR)-containing protein (SGT) that may control or protect the assembly and activity of SNARE proteins and various other protein substrates. Here, the author summarizes studies that elucidated CSP's neuroprotective role.

Original languageEnglish (US)
Pages (from-to)120-132
Number of pages13
JournalJournal of Neurogenetics
Volume24
Issue number3
DOIs
StatePublished - Sep 2010

Fingerprint

SNARE Proteins
Synaptic Vesicles
Glutamine
Neurotransmitter Agents
Shock
Proteins
Hot Temperature
cysteine string protein

Keywords

  • cysteine-string protein
  • neurodegeneration
  • neurotransmitter release
  • synaptic vesicle

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Genetics

Cite this

Cysteine-string protein's neuroprotective role. / Zinsmaier, Konrad E.

In: Journal of Neurogenetics, Vol. 24, No. 3, 09.2010, p. 120-132.

Research output: Contribution to journalArticle

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