Cystic hygroma reconsidered: Hamartoma or neoplasm? Primary culture of an endothelial cell line from a massive cervicomediastinal hygroma with bony lymphangiomatosis

C. A. Bowman, M. H. Witte, C. L. Witte, D. L. Way, R. B. Nagle, J. G. Copeland, C. C. Daschbach

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A young woman presented with massive enlargement of a giant cervicomediastinal cystic hygroma, which communicated in part with the thoracic duct and was associated with generalized bony lymphangiomatosis. Modern imaging and sophisticated intraoperative physiologic monitoring made one-stage resection feasible. Tissue culture of explants of the hygroma yielded a primary endothelial cell line still surviving after 18 months, which, like the cyst-lining endothelium in the original resected specimen, reacted positively for Factor VIII-associated antigen. These findings, in conjunction with the histologic picture, support the notion that cystic hygroma represents an expanding proliferatng endothelial growth process and not simply a sequestered lymphatic receptacle.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalLymphology
Volume17
Issue number1
StatePublished - 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology

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