ETUDE CYTO-ENZYMOLOGIQUE DES PLASMOCYTES MEDULLAIRES DES DYSGLOBULINEMIES MONOCLONALES MYELOMATEUSES ET NON MYELOMATEUSES

Translated title of the contribution: Cytochemical studies of bone marrow plasma cells in monoclonal gammapathies

A. Miliani, P. Anichini, R. di Guglielmo, G. Pellegrini, C. Firorelli, A. Cuccuini, F. Cozzolino, Donata Vercelli

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Three plasma cell enzymatic reactions - ATPase, acid phosphatase (AP), α-naphthyl acetate esterase (α-NAE) - were tested in a large number of bone marrow samples from patients with multiple myeloma (MM), benign monoclonal gammapathy (BMG) - idiopathic (iBMG) and secondary (sBMG) - polyclonal hypergammaglobulinemia (PH), Waldenstrom's macroglobulinemia (WM) and from normoglobulinemic subjects (NS). The purpose of the present study was to evaluate the significance of these reactions in differential diagnosis of BMG and initial or atypical MM. For each reaction results were expressed as scores and normal limits were statistically established. Our findings in MM, HPO and NS are consistent with previous reports (similar enzymatic pattern in NS and PH; depressed ATPase acivity, raised AP and α-NAE activities in most MM cases). In the BMG class, ATPase activity was normal in about 40% of iBMG, while it was depressed in the other cases; most sBMG had diminished ATPase activity. AP patterns were normal for both BMG groups. α-NAE activity was normal in 50% of iBMG, while it was raised in the other cases. All the reactions were normal in WM. In a bayesian analysis of cytochemical patterns of NS and MM subjects ATPase showed the highest diagnostic significance, followed by α-NAE and AP ATPase, therefore, seems to be the most useful criterion for the diagnosis of initial MM; low ATPase score BMG patients should therefore be carefully followed-up.

Original languageFrench
Pages (from-to)27-33
Number of pages7
JournalNouvelle Revue Francaise d'Hematologie
Volume24
Issue number1
StatePublished - 1982
Externally publishedYes

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Paraproteinemias
Plasma Cells
Monoclonal Gammopathy of Undetermined Significance
Bone Marrow Cells
Adenosine Triphosphatases
Multiple Myeloma
Acid Phosphatase
Hypergammaglobulinemia
Waldenstrom Macroglobulinemia
Acetylesterase
Bayes Theorem
Differential Diagnosis
Bone Marrow

ASJC Scopus subject areas

  • Hematology

Cite this

ETUDE CYTO-ENZYMOLOGIQUE DES PLASMOCYTES MEDULLAIRES DES DYSGLOBULINEMIES MONOCLONALES MYELOMATEUSES ET NON MYELOMATEUSES. / Miliani, A.; Anichini, P.; di Guglielmo, R.; Pellegrini, G.; Firorelli, C.; Cuccuini, A.; Cozzolino, F.; Vercelli, Donata.

In: Nouvelle Revue Francaise d'Hematologie, Vol. 24, No. 1, 1982, p. 27-33.

Research output: Contribution to journalArticle

Miliani, A, Anichini, P, di Guglielmo, R, Pellegrini, G, Firorelli, C, Cuccuini, A, Cozzolino, F & Vercelli, D 1982, 'ETUDE CYTO-ENZYMOLOGIQUE DES PLASMOCYTES MEDULLAIRES DES DYSGLOBULINEMIES MONOCLONALES MYELOMATEUSES ET NON MYELOMATEUSES', Nouvelle Revue Francaise d'Hematologie, vol. 24, no. 1, pp. 27-33.
Miliani, A. ; Anichini, P. ; di Guglielmo, R. ; Pellegrini, G. ; Firorelli, C. ; Cuccuini, A. ; Cozzolino, F. ; Vercelli, Donata. / ETUDE CYTO-ENZYMOLOGIQUE DES PLASMOCYTES MEDULLAIRES DES DYSGLOBULINEMIES MONOCLONALES MYELOMATEUSES ET NON MYELOMATEUSES. In: Nouvelle Revue Francaise d'Hematologie. 1982 ; Vol. 24, No. 1. pp. 27-33.
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