Cytogenetics of bone marrow fibroblastic cells in idiopathic chronic myelofibrosis

B. R. Greenberg, L. Woo, I. C. Veomett, C. M. Payne, F. R. Ahmann

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

To determine the nature of the fibroblastic proliferation in myelofibrosis, we studied the cytogenetic composition of a pure population of in-vitro bone marrow fibroblastic cells (FC) from a patient with idiopathic chronic myelofibrosis who had trisomy 8 in her unstimulated peripheral blood cells. This cytogenic abnormality was absent in all the FC studied supporting the premise that in the myeloproliferative disorders the myelofibrosis represents a secondary or non-neoplastic reaction to the clonal proliferation of haematopoietic stem cells.

Original languageEnglish (US)
Pages (from-to)487-490
Number of pages4
JournalBritish Journal of Haematology
Volume66
Issue number4
DOIs
StatePublished - Jan 1 1987

    Fingerprint

ASJC Scopus subject areas

  • Hematology

Cite this