TY - JOUR
T1 - Cytokine genotype and phenotype effects on lung function decline in firefighters
AU - Josyula, Arun B.
AU - Kurzius-Spencer, Margaret
AU - Littau, Sally R.
AU - Yucesoy, Berran
AU - Fleming, James
AU - Burgess, Jefferey L.
PY - 2007/3/1
Y1 - 2007/3/1
N2 - OBJECTIVE: We conducted this study to evaluate the association of cytokine genotypes and sputum concentrations on longitudinal decline in lung function in firefighters. METHODS: In 67 firefighters with at least four pulmonary function tests, DNA was analyzed for functional polymorphisms of interleukin (IL)-1β, IL-1 receptor antagonist (IL-1RA), IL-8, IL-10, tumor necrosis factor-alpha (TNF-α) genes, and sputum evaluated for cytokine concentration by ELISA. RESULTS: The annual rate of FEV1 decline was greater in firefighters with TT genotypes at IL-10 (-819) (P = 0.009) and with CT or TT genotypes at IL-1RA (2018) (P = 0.050). These genotypes were not associated with concentrations of sputum cytokine, but increased IL-1RA was associated with a slower rate of FEV1 decline (P = 0.025), as was increased sputum macrophage count (P = 0.002). CONCLUSIONS: Cytokine genotypes were associated with the rate of FEV1 decline but did not alter concentrations of sputum cytokine. Increased sputum IL-1RA may be protective.
AB - OBJECTIVE: We conducted this study to evaluate the association of cytokine genotypes and sputum concentrations on longitudinal decline in lung function in firefighters. METHODS: In 67 firefighters with at least four pulmonary function tests, DNA was analyzed for functional polymorphisms of interleukin (IL)-1β, IL-1 receptor antagonist (IL-1RA), IL-8, IL-10, tumor necrosis factor-alpha (TNF-α) genes, and sputum evaluated for cytokine concentration by ELISA. RESULTS: The annual rate of FEV1 decline was greater in firefighters with TT genotypes at IL-10 (-819) (P = 0.009) and with CT or TT genotypes at IL-1RA (2018) (P = 0.050). These genotypes were not associated with concentrations of sputum cytokine, but increased IL-1RA was associated with a slower rate of FEV1 decline (P = 0.025), as was increased sputum macrophage count (P = 0.002). CONCLUSIONS: Cytokine genotypes were associated with the rate of FEV1 decline but did not alter concentrations of sputum cytokine. Increased sputum IL-1RA may be protective.
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U2 - 10.1097/JOM.0b013e3180322584
DO - 10.1097/JOM.0b013e3180322584
M3 - Article
C2 - 17351514
AN - SCOPUS:33947172557
VL - 49
SP - 282
EP - 288
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
SN - 1076-2752
IS - 3
ER -