Cytologic studies of the fallopian tube in patients undergoing salpingo-oophorectomy

Hao Chen, Robert Klein, Stacy Arnold, Setsuko K Chambers, Wenxin - Zheng

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Mounting evidence suggests the fallopian tube as the origin for ovarian high grade serous carcinoma (HGSC). We attempted to identify the tubal cytological features that allow us to distinguish malignant from benign conditions. Methods: Tubal specimens (n = 56) were collected from patients who underwent bilateral salpingo-oophorectomy (BSO) due to various clinical indications. A standard procedure to collect fallopian tube brushings from freshly received surgical specimens was developed. Cytological diagnoses were classified into three categories: benign, atypical, and suspicious for malignancy/malignant. Cytological variables of individual cells and epithelia were subjected to statistical analysis. The fallopian tube histology was used as diagnostic reference for confirmation of cytology diagnosis. Results: Among the 56 fallopian tube specimens, 2 (3.7 %) showed inadequate cellularity preventing further evaluation, 11 (20.4 %) were diagnosed as malignant or suspicious of malignancy, 7 were atypical, and 36 were benign. The presence of three dimensional clusters (p < 0.0001, Fisher's Exact Test), or prominent nucleoli (p = 0.0252, Fisher Exact test) was highly correlated with the diagnosis of malignancy. The suspicious malignant/malignant cytological diagnosis was also highly correlated with presence of HGSC with or without serous tubal intraepithelial carcinoma (STIC). Conclusions: Tubal cytology may be useful for ovarian cancer screening and early detection.

Original languageEnglish (US)
Article number78
JournalCancer Cell International
Volume16
Issue number1
DOIs
StatePublished - Oct 1 2016

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Fallopian Tubes
Ovariectomy
Cell Biology
Carcinoma
Neoplasms
Carcinoma in Situ
Early Detection of Cancer
Ovarian Neoplasms
Histology
Epithelium

Keywords

  • Atypical cytology
  • Early detection
  • High-grade serous carcinoma
  • Serous tubal intraepithelial carcinoma
  • Tubal cytology

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

Cite this

Cytologic studies of the fallopian tube in patients undergoing salpingo-oophorectomy. / Chen, Hao; Klein, Robert; Arnold, Stacy; Chambers, Setsuko K; Zheng, Wenxin -.

In: Cancer Cell International, Vol. 16, No. 1, 78, 01.10.2016.

Research output: Contribution to journalArticle

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abstract = "Background: Mounting evidence suggests the fallopian tube as the origin for ovarian high grade serous carcinoma (HGSC). We attempted to identify the tubal cytological features that allow us to distinguish malignant from benign conditions. Methods: Tubal specimens (n = 56) were collected from patients who underwent bilateral salpingo-oophorectomy (BSO) due to various clinical indications. A standard procedure to collect fallopian tube brushings from freshly received surgical specimens was developed. Cytological diagnoses were classified into three categories: benign, atypical, and suspicious for malignancy/malignant. Cytological variables of individual cells and epithelia were subjected to statistical analysis. The fallopian tube histology was used as diagnostic reference for confirmation of cytology diagnosis. Results: Among the 56 fallopian tube specimens, 2 (3.7 {\%}) showed inadequate cellularity preventing further evaluation, 11 (20.4 {\%}) were diagnosed as malignant or suspicious of malignancy, 7 were atypical, and 36 were benign. The presence of three dimensional clusters (p < 0.0001, Fisher's Exact Test), or prominent nucleoli (p = 0.0252, Fisher Exact test) was highly correlated with the diagnosis of malignancy. The suspicious malignant/malignant cytological diagnosis was also highly correlated with presence of HGSC with or without serous tubal intraepithelial carcinoma (STIC). Conclusions: Tubal cytology may be useful for ovarian cancer screening and early detection.",
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