Cytomegalovirus infection after autologous bone marrow transplantation with comparison to infection after allogeneic bone marrow transplantation

J. R. Wingard, D. Y.H. Chen, W. H. Burns, D. J. Fuller, H. G. Braine, A. M. Yeager, H. Kaiser, P. J. Burke, M. L. Graham, G. W. Santos, R. Saral

Research output: Contribution to journalArticle

166 Scopus citations

Abstract

Cytomegalovirus (CMV) infection was detected in 65 of 143 (45%) autologous bone marrow transplant (BMT) patients. CMV pneumonitis occurred in only 2% of the patients and CMV retinitis occurred in none. Infection occurred in half of the 40 initially seronegative patients and 47% of the 94 initially seropositive patients. Among initially seropositive patients, platelet recovery was slower in infected patients than in those not infected (97 vs 35 days median, P = .003), and neutrophil recovery was slightly delayed in infected patients (31 days v 24 days, P = .02). Although the incidence of CMV infection was comparable in autologous and allogeneic BMT patients, CMV pneumonitis was less frequent in autologous BMT patients (2% v 12%, P < .001). The risk for CMV pneumonitis in autologous BMT patients was comparable with that in allogeneic BMT patients was comparable with that in allogeneic BMT patients without graft-v-host disease (GVHD) (2% v 6%), but significantly lower than the risk in allogeneic BMT patients with GVHD (2% v 23%, P < .001).

Original languageEnglish (US)
Pages (from-to)1432-1437
Number of pages6
JournalBlood
Volume71
Issue number5
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Wingard, J. R., Chen, D. Y. H., Burns, W. H., Fuller, D. J., Braine, H. G., Yeager, A. M., Kaiser, H., Burke, P. J., Graham, M. L., Santos, G. W., & Saral, R. (1988). Cytomegalovirus infection after autologous bone marrow transplantation with comparison to infection after allogeneic bone marrow transplantation. Blood, 71(5), 1432-1437. https://doi.org/10.1182/blood.v71.5.1432.1432