Cytoskeletal conformational automata: Intra-neuronal support of neural networks

Stuart R Hameroff, Judith Dayhoff, Djuro Koruga

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The cytoskeleton, a lattice polymer network supporting shape and internal communication within living cells, may compute at the molecular level. We propose a set of models for computing within cytoskeletal filamentous polymers: microtubules ("MTs"), actin, intermediate filaments and cross-bridging microtubule-associated proteins ("MAPs"). Signals and information may be represented and transmitted via propagated conformational changes of these structures' subunits which locally interact via "cellular automata-like" interactions. Conformational automata (based on dipole-coupled coherent 10″ to 10′ sec cytoskeletal subunit excitations) may recognize and adapt to neuronal membrane and synaptic events (via second messenger systems) by changing conformational automata patterns, modifying MAP-MT connections (and thus neural architecture and synaptic function) and retrograde signaling. These cytoskeletal functions may subserve dendritic processing, ANN-like paradigms such as back-error propagation and provide a primary medium for neuronal information processing and storage.

Original languageEnglish (US)
Title of host publicationConference Proceedings - IEEE International Conference on Systems, Man and Cybernetics
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages84-88
Number of pages5
Volume1992-January
ISBN (Print)0780307208, 9780780307209
DOIs
StatePublished - 1992
Externally publishedYes
EventIEEE International Conference on Systems, Man, and Cybernetics, SMC 1992 - Chicago, United States
Duration: Oct 18 1992Oct 21 1992

Other

OtherIEEE International Conference on Systems, Man, and Cybernetics, SMC 1992
CountryUnited States
CityChicago
Period10/18/9210/21/92

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ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Control and Systems Engineering
  • Human-Computer Interaction

Cite this

Hameroff, S. R., Dayhoff, J., & Koruga, D. (1992). Cytoskeletal conformational automata: Intra-neuronal support of neural networks. In Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics (Vol. 1992-January, pp. 84-88). [271797] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICSMC.1992.271797