Cytoskeletal conformational automata: Intra-neuronal support of neural networks

Stuart Hameroff, Judith Dayhoff, Djuro Koruga

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The cytoskeleton, a lattice polymer network supporting shape and internal communication within living cells, may compute at the molecular level. We propose a set of models for computing within cytoskeletal filamentous polymers: microtubules ("MTs"), actin, intermediate filaments and cross-bridging microtubule-associated proteins ("MAPs"). Signals and information may be represented and transmitted via propagated conformational changes of these structures' subunits which locally interact via "cellular automata-like" interactions. Conformational automata (based on dipole-coupled coherent 10″ to 10′ sec cytoskeletal subunit excitations) may recognize and adapt to neuronal membrane and synaptic events (via second messenger systems) by changing conformational automata patterns, modifying MAP-MT connections (and thus neural architecture and synaptic function) and retrograde signaling. These cytoskeletal functions may subserve dendritic processing, ANN-like paradigms such as back-error propagation and provide a primary medium for neuronal information processing and storage.

Original languageEnglish (US)
Title of host publication1992 IEEE International Conference on Systems, Man, and Cybernetics
Subtitle of host publicationEmergent Innovations in Information Transfer Processing and Decision Making, SMC 1992
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages84-88
Number of pages5
ISBN (Electronic)0780307208, 9780780307209
DOIs
StatePublished - 1992
Externally publishedYes
EventIEEE International Conference on Systems, Man, and Cybernetics, SMC 1992 - Chicago, United States
Duration: Oct 18 1992Oct 21 1992

Publication series

NameConference Proceedings - IEEE International Conference on Systems, Man and Cybernetics
Volume1992-January
ISSN (Print)1062-922X

Other

OtherIEEE International Conference on Systems, Man, and Cybernetics, SMC 1992
CountryUnited States
CityChicago
Period10/18/9210/21/92

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Control and Systems Engineering
  • Human-Computer Interaction

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