Cytoskeleton-Inspired Artificial Protein Design to Enhance Polymer Network Elasticity

David S. Knoff, Haley Szczublewski, Dallas Altamirano, Kareen A. Fajardo Cortes, Minkyu Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Reducing topological network defects to enhance elasticity in polymeric materials remains a grand challenge. Efforts to control network topology, primarily focused on cross-linking junctions, continue to underperform compared to theoretical estimations from idealized networks using affine and phantom network theories. Here, artificial protein technology was adapted for the design of polymer-network hydrogels with precisely defined coil-like and rod-like strands to observe the impact of strand rigidity on the mechanical properties of polymeric materials. Cytoskeleton-inspired polymer-network hydrogels incorporated with rod-like protein strands nearly tripled the gel shear elastic modulus and relaxation time compared to coil-like protein strands, indicating an enhanced effective cross-linking density. Furthermore, asymmetric rod-coil protein designs in network strands with an optimal rod/coil ratio improved the hydrogel relaxation time, enhancing the stability of physical macromolecular associations by modulating the cross-linker mobility. The careful design of strand rigidity presents a new direction to reduce topological defects for optimizing polymeric materials.

Original languageEnglish (US)
Pages (from-to)3464-3471
Number of pages8
JournalMacromolecules
Volume53
Issue number9
DOIs
StatePublished - May 12 2020

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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