Abstract
The isolation and identification of deoxypodophyllotoxin and a new lignan, 5′‐desmethoxydeoxypodophyllotoxin, from the dried exudate of Bursera morelensis (Burseraceae) are reported. Deoxypodophyllotoxin showed high activity in the KB and PS test systems; the new lignan, although highly active against the KB test system, demonstrated only marginal activity against the PS test system. A structure is suggested for the new lignan, which was named morelensin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 892-893 |
| Number of pages | 2 |
| Journal | Journal of pharmaceutical sciences |
| Volume | 66 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1977 |
Keywords
- Bursera morelensis—deoxypodophyllotoxin and 5′‐des‐methoxy derivative isolated from dried exudate, cytotoxic activity evaluated
- Cytotoxic activity—deoxypodophyllotoxin and 5′‐des‐methoxy derivative evaluated
- Deoxypodophyllotoxin—and 5′‐desmethoxy derivative, isolated from dried exudate of Bursera morelensis, cytotoxic activity evaluated
ASJC Scopus subject areas
- Pharmaceutical Science
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Jolad, S. D., Wiedhopf, R. M., & Cole, J. R. (1977). Cytotoxic agents from Bursera morelensis (Burseraceae): Deoxypodophyllotoxin and a new lignan, 5′‐desmethoxydeoxypodophyllotoxin. Journal of pharmaceutical sciences, 66(6), 892-893. https://doi.org/10.1002/jps.2600660647