TY - JOUR
T1 - Cytotoxic agents from Bursera morelensis (Burseraceae)
T2 - Deoxypodophyllotoxin and a new lignan, 5′‐desmethoxydeoxypodophyllotoxin
AU - Jolad, S. D.
AU - Wiedhopf, R. M.
AU - Cole, J. R.
N1 - Funding Information:
6 2.9 (3H, m), 3.79 (3H, s),3 .86 (3H, s), 3.9 (2H, m), 4.5 (2H, m), 5.90 (2H, IR (CHC13: 3000,2900,2840,2780,1775, and 930 cm-'), NMR [CDCh: Supported in part by Contract N01-CM-3-3750f rom the Division of ~),6.37(1H,dd,J=8and2Hz),6.49(1H,s),6.66(1H,s),6.67(1H,d,J Cancer Treatment, National Cancer Institute, National Institutes of = 8 Hz),a nd 6.90 (lH, d, J = 2 Hz)],a nd mass [mle 368 (M+, base), 353, Health, Bethesda, MD 20014, and the Elsa U. Pardee Foundation, 340,338,337,323,309,308,253,230,212,185,151,138,a9n5d, 7 71 spectra Midland, MI 48640. were in accord with Structure 11. This compound was optically active, The authors are grateful to Drug Research and Development, Che- [ a ]- ~125Õ (c 0.014 in chloroform). motherapy, National Cancer Institute, for supplying authentic samples Anal.-Calc. for C21H2006: C, 68.47; H, 5.7f; mol. wt. 368. Found: C, of deoxypodophyllotoxin. 68.47; H, 5.47; mle 368 (M+). To whom inquiries should be directed.
PY - 1977/6
Y1 - 1977/6
N2 - The isolation and identification of deoxypodophyllotoxin and a new lignan, 5′‐desmethoxydeoxypodophyllotoxin, from the dried exudate of Bursera morelensis (Burseraceae) are reported. Deoxypodophyllotoxin showed high activity in the KB and PS test systems; the new lignan, although highly active against the KB test system, demonstrated only marginal activity against the PS test system. A structure is suggested for the new lignan, which was named morelensin.
AB - The isolation and identification of deoxypodophyllotoxin and a new lignan, 5′‐desmethoxydeoxypodophyllotoxin, from the dried exudate of Bursera morelensis (Burseraceae) are reported. Deoxypodophyllotoxin showed high activity in the KB and PS test systems; the new lignan, although highly active against the KB test system, demonstrated only marginal activity against the PS test system. A structure is suggested for the new lignan, which was named morelensin.
KW - Bursera morelensis—deoxypodophyllotoxin and 5′‐des‐methoxy derivative isolated from dried exudate, cytotoxic activity evaluated
KW - Cytotoxic activity—deoxypodophyllotoxin and 5′‐des‐methoxy derivative evaluated
KW - Deoxypodophyllotoxin—and 5′‐desmethoxy derivative, isolated from dried exudate of Bursera morelensis, cytotoxic activity evaluated
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U2 - 10.1002/jps.2600660647
DO - 10.1002/jps.2600660647
M3 - Article
C2 - 559755
AN - SCOPUS:0017683764
VL - 66
SP - 892
EP - 893
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 6
ER -