Cytotoxic agents from Bursera morelensis (Burseraceae): Deoxypodophyllotoxin and a new lignan, 5′‐desmethoxydeoxypodophyllotoxin

S. D. Jolad, R. M. Wiedhopf, J. R. Cole

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The isolation and identification of deoxypodophyllotoxin and a new lignan, 5′‐desmethoxydeoxypodophyllotoxin, from the dried exudate of Bursera morelensis (Burseraceae) are reported. Deoxypodophyllotoxin showed high activity in the KB and PS test systems; the new lignan, although highly active against the KB test system, demonstrated only marginal activity against the PS test system. A structure is suggested for the new lignan, which was named morelensin.

Original languageEnglish (US)
Pages (from-to)892-893
Number of pages2
JournalJournal of pharmaceutical sciences
Volume66
Issue number6
DOIs
StatePublished - Jun 1977

Keywords

  • Bursera morelensis—deoxypodophyllotoxin and 5′‐des‐methoxy derivative isolated from dried exudate, cytotoxic activity evaluated
  • Cytotoxic activity—deoxypodophyllotoxin and 5′‐des‐methoxy derivative evaluated
  • Deoxypodophyllotoxin—and 5′‐desmethoxy derivative, isolated from dried exudate of Bursera morelensis, cytotoxic activity evaluated

ASJC Scopus subject areas

  • Pharmaceutical Science

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