Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica

Ya Ming Xu, E. M.Kithsiri Wijeratne, Alan D. Brooks, Poonam Tewary, Li Jiang Xuan, Wen Qiong Wang, Thomas J. Sayers, Leslie Gunatilaka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Eleven withanolides including six previously undescribed compounds, 16β-hydroxyixocarpanolide, 24,25-dihydroexodeconolide C, 16,17-dehydro-24-epi-dioscorolide A, 17-epi-philadelphicalactone A, 16-deoxyphiladelphicalactone C, and 4-deoxyixocarpalactone A were isolated from aeroponically grown Physalis philadelphica. Structures of these withanolides were elucidated by the analysis of their spectroscopic (HRMS, 1D and 2D NMR, ECD) data and comparison with published data for related withanolides. Cytotoxic activity of all isolated compounds was evaluated against a panel of five human tumor cell lines (LNCaP, ACHN, UO-31, M14 and SK-MEL-28), and normal (HFF) cells. Of these, 17-epi-philadelphicalactone A, withaphysacarpin, philadelphicalactone C, and ixocarpalactone A exhibited cytotoxicity against ACHN, UO-31, M14 and SK-MEL-28, but showed no toxicity to HFF cells.

Original languageEnglish (US)
Pages (from-to)174-181
Number of pages8
JournalPhytochemistry
Volume152
DOIs
StatePublished - Aug 1 2018

Fingerprint

Withanolides
Physalis philadelphica
Physalis
cytotoxicity
cell lines
cells
Cytotoxicity
toxicity
Tumor Cell Line
Toxicity
Tumors
Cells
Nuclear magnetic resonance

Keywords

  • Aeroponic cultivation
  • Chemical investigation
  • Cytotoxic activity
  • Physalis philadelphica
  • Solanaceae
  • Withanolides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

Cite this

Xu, Y. M., Wijeratne, E. M. K., Brooks, A. D., Tewary, P., Xuan, L. J., Wang, W. Q., ... Gunatilaka, L. (2018). Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica. Phytochemistry, 152, 174-181. https://doi.org/10.1016/j.phytochem.2018.04.018

Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica. / Xu, Ya Ming; Wijeratne, E. M.Kithsiri; Brooks, Alan D.; Tewary, Poonam; Xuan, Li Jiang; Wang, Wen Qiong; Sayers, Thomas J.; Gunatilaka, Leslie.

In: Phytochemistry, Vol. 152, 01.08.2018, p. 174-181.

Research output: Contribution to journalArticle

Xu, YM, Wijeratne, EMK, Brooks, AD, Tewary, P, Xuan, LJ, Wang, WQ, Sayers, TJ & Gunatilaka, L 2018, 'Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica', Phytochemistry, vol. 152, pp. 174-181. https://doi.org/10.1016/j.phytochem.2018.04.018
Xu YM, Wijeratne EMK, Brooks AD, Tewary P, Xuan LJ, Wang WQ et al. Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica. Phytochemistry. 2018 Aug 1;152:174-181. https://doi.org/10.1016/j.phytochem.2018.04.018
Xu, Ya Ming ; Wijeratne, E. M.Kithsiri ; Brooks, Alan D. ; Tewary, Poonam ; Xuan, Li Jiang ; Wang, Wen Qiong ; Sayers, Thomas J. ; Gunatilaka, Leslie. / Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica. In: Phytochemistry. 2018 ; Vol. 152. pp. 174-181.
@article{64511d5ff2a1427a9007fff4399aff77,
title = "Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica",
abstract = "Eleven withanolides including six previously undescribed compounds, 16β-hydroxyixocarpanolide, 24,25-dihydroexodeconolide C, 16,17-dehydro-24-epi-dioscorolide A, 17-epi-philadelphicalactone A, 16-deoxyphiladelphicalactone C, and 4-deoxyixocarpalactone A were isolated from aeroponically grown Physalis philadelphica. Structures of these withanolides were elucidated by the analysis of their spectroscopic (HRMS, 1D and 2D NMR, ECD) data and comparison with published data for related withanolides. Cytotoxic activity of all isolated compounds was evaluated against a panel of five human tumor cell lines (LNCaP, ACHN, UO-31, M14 and SK-MEL-28), and normal (HFF) cells. Of these, 17-epi-philadelphicalactone A, withaphysacarpin, philadelphicalactone C, and ixocarpalactone A exhibited cytotoxicity against ACHN, UO-31, M14 and SK-MEL-28, but showed no toxicity to HFF cells.",
keywords = "Aeroponic cultivation, Chemical investigation, Cytotoxic activity, Physalis philadelphica, Solanaceae, Withanolides",
author = "Xu, {Ya Ming} and Wijeratne, {E. M.Kithsiri} and Brooks, {Alan D.} and Poonam Tewary and Xuan, {Li Jiang} and Wang, {Wen Qiong} and Sayers, {Thomas J.} and Leslie Gunatilaka",
year = "2018",
month = "8",
day = "1",
doi = "10.1016/j.phytochem.2018.04.018",
language = "English (US)",
volume = "152",
pages = "174--181",
journal = "Phytochemistry",
issn = "0031-9422",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica

AU - Xu, Ya Ming

AU - Wijeratne, E. M.Kithsiri

AU - Brooks, Alan D.

AU - Tewary, Poonam

AU - Xuan, Li Jiang

AU - Wang, Wen Qiong

AU - Sayers, Thomas J.

AU - Gunatilaka, Leslie

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Eleven withanolides including six previously undescribed compounds, 16β-hydroxyixocarpanolide, 24,25-dihydroexodeconolide C, 16,17-dehydro-24-epi-dioscorolide A, 17-epi-philadelphicalactone A, 16-deoxyphiladelphicalactone C, and 4-deoxyixocarpalactone A were isolated from aeroponically grown Physalis philadelphica. Structures of these withanolides were elucidated by the analysis of their spectroscopic (HRMS, 1D and 2D NMR, ECD) data and comparison with published data for related withanolides. Cytotoxic activity of all isolated compounds was evaluated against a panel of five human tumor cell lines (LNCaP, ACHN, UO-31, M14 and SK-MEL-28), and normal (HFF) cells. Of these, 17-epi-philadelphicalactone A, withaphysacarpin, philadelphicalactone C, and ixocarpalactone A exhibited cytotoxicity against ACHN, UO-31, M14 and SK-MEL-28, but showed no toxicity to HFF cells.

AB - Eleven withanolides including six previously undescribed compounds, 16β-hydroxyixocarpanolide, 24,25-dihydroexodeconolide C, 16,17-dehydro-24-epi-dioscorolide A, 17-epi-philadelphicalactone A, 16-deoxyphiladelphicalactone C, and 4-deoxyixocarpalactone A were isolated from aeroponically grown Physalis philadelphica. Structures of these withanolides were elucidated by the analysis of their spectroscopic (HRMS, 1D and 2D NMR, ECD) data and comparison with published data for related withanolides. Cytotoxic activity of all isolated compounds was evaluated against a panel of five human tumor cell lines (LNCaP, ACHN, UO-31, M14 and SK-MEL-28), and normal (HFF) cells. Of these, 17-epi-philadelphicalactone A, withaphysacarpin, philadelphicalactone C, and ixocarpalactone A exhibited cytotoxicity against ACHN, UO-31, M14 and SK-MEL-28, but showed no toxicity to HFF cells.

KW - Aeroponic cultivation

KW - Chemical investigation

KW - Cytotoxic activity

KW - Physalis philadelphica

KW - Solanaceae

KW - Withanolides

UR - http://www.scopus.com/inward/record.url?scp=85047088363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047088363&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2018.04.018

DO - 10.1016/j.phytochem.2018.04.018

M3 - Article

C2 - 29775868

AN - SCOPUS:85047088363

VL - 152

SP - 174

EP - 181

JO - Phytochemistry

JF - Phytochemistry

SN - 0031-9422

ER -