Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica

Ya Ming Xu, E. M.Kithsiri Wijeratne, Alan D. Brooks, Poonam Tewary, Li Jiang Xuan, Wen Qiong Wang, Thomas J. Sayers, Leslie Gunatilaka

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Eleven withanolides including six previously undescribed compounds, 16β-hydroxyixocarpanolide, 24,25-dihydroexodeconolide C, 16,17-dehydro-24-epi-dioscorolide A, 17-epi-philadelphicalactone A, 16-deoxyphiladelphicalactone C, and 4-deoxyixocarpalactone A were isolated from aeroponically grown Physalis philadelphica. Structures of these withanolides were elucidated by the analysis of their spectroscopic (HRMS, 1D and 2D NMR, ECD) data and comparison with published data for related withanolides. Cytotoxic activity of all isolated compounds was evaluated against a panel of five human tumor cell lines (LNCaP, ACHN, UO-31, M14 and SK-MEL-28), and normal (HFF) cells. Of these, 17-epi-philadelphicalactone A, withaphysacarpin, philadelphicalactone C, and ixocarpalactone A exhibited cytotoxicity against ACHN, UO-31, M14 and SK-MEL-28, but showed no toxicity to HFF cells.

Original languageEnglish (US)
Pages (from-to)174-181
Number of pages8
JournalPhytochemistry
Volume152
DOIs
StatePublished - Aug 1 2018

Keywords

  • Aeroponic cultivation
  • Chemical investigation
  • Cytotoxic activity
  • Physalis philadelphica
  • Solanaceae
  • Withanolides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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  • Cite this

    Xu, Y. M., Wijeratne, E. M. K., Brooks, A. D., Tewary, P., Xuan, L. J., Wang, W. Q., Sayers, T. J., & Gunatilaka, L. (2018). Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica. Phytochemistry, 152, 174-181. https://doi.org/10.1016/j.phytochem.2018.04.018