Cytotoxic and tumor inhibitory agent from Polygala macradenia Gray (Polygalaceae): 4'-demethyldeoxypodophyllotoxin.

J. J. Hoffmann, R. M. Wiedhopf, Jack R Cole

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The chloroform fraction of Polygala macradenia exhibited activity against the P-388 lymphocytic leukemia and human epidermoid carcinoma of the nasopharynx test systems. The constituent responsible for this activity was a lignan, 4'-demethyldeoxypodophyllotoxin (C21H20O7). The identity was proven by elemental analysis; PMR, IR, mass spectrometric, and melting-point determinations; and preparation of a derivative.

Original languageEnglish (US)
Pages (from-to)586-587
Number of pages2
JournalJournal of Pharmaceutical Sciences
Volume66
Issue number4
StatePublished - Apr 1977

Fingerprint

Polygalaceae
Polygala
Lymphoid Leukemia
Lignans
Nasopharynx
Chloroform
Freezing
Melting point
Tumors
Squamous Cell Carcinoma
Derivatives
Chemical analysis
Neoplasms

ASJC Scopus subject areas

  • Molecular Medicine
  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

Cite this

Cytotoxic and tumor inhibitory agent from Polygala macradenia Gray (Polygalaceae) : 4'-demethyldeoxypodophyllotoxin. / Hoffmann, J. J.; Wiedhopf, R. M.; Cole, Jack R.

In: Journal of Pharmaceutical Sciences, Vol. 66, No. 4, 04.1977, p. 586-587.

Research output: Contribution to journalArticle

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