Cytotoxic and tumor inhibitory agent from Polygala macradenia gray (Polygalaceae): 4′‐demethyldeoxypodophyllotoxin

Joseph J. Hoffmann, Richard M. Wiedhopf, Jack R. Cole

Research output: Contribution to journalComment/debatepeer-review

14 Scopus citations

Abstract

The chloroform fraction of Polygala macradenia exhibited activity against the P‐388 lymphocytic leukemia and human epidermoid carcinoma of the nasopharynx test systems. The constituent responsible for this activity was a lignan, 4′‐demethyldeoxypodophyllotoxin (C21H20C7). The identity was proven by elemental analysis; PMR, IR, mass spectrometric, and melting‐point determinations; and preparation of a derivative.

Original languageEnglish (US)
Pages (from-to)586-587
Number of pages2
JournalJournal of pharmaceutical sciences
Volume66
Issue number4
DOIs
StatePublished - Apr 1977

Keywords

  • 4′‐Demethyldeoxypodophyllotoxin—isolated from chloroform fraction of extract of aerial parts of Polygala macradenia, evaluated for cytotoxic and tumor inhibitory activity
  • Cytotoxic activity—lignan isolated from chloroform fraction of extract of aerial parts of Polygala macradenia evaluated
  • Polygala macradenia—chloroform fraction of extract of aerial parts, lignan isolated, evaluated for cytotoxic and tumor inhibitory activity
  • Tumor inhibitory activity—lignan isolated from chloroform fraction of extract of aerial parts of Polygala macradenia evaluated

ASJC Scopus subject areas

  • Pharmaceutical Science

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