Cytotoxic cytochalasins and other metabolites from xylariaceae sp. FL0390, a fungal endophyte of Spanish moss

Ya Ming Xu, Bharat P. Bashyal, Mangping X. Liu, Patricia Espinosa-Artiles, Jana M. U'Ren, A. Elizabeth Arnold, A. A.Leslie Gunatilaka

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Two new metabolites, 6-oxo-12-norcytochalasin D (1) and 4,5-di-isobutyl-2(1H)-pyrimidinone (2), together with seven known metabolites, cytochalasins D (3), Q (4), and N (5), 12-hydroxyzygosporin G (6), heptelidic acid chlorohydrin (7), (+)-heptelidic acid (8), and trichoderonic acid A (9), were isolated from Xylariaceae sp. FL0390, a fungal endophyte inhabiting Spanish moss, Tillandsia usneoides. Metabolite 1 is the first example of a 12-norcytochalasin. All metabolites, except 2 and 9, showed cytotoxic activity in a panel of five human tumor cell lines with IC50s of 0.2-5.0 μM.

Original languageEnglish (US)
Pages (from-to)1655-1658
Number of pages4
JournalNatural Product Communications
Volume10
Issue number10
DOIs
StatePublished - Oct 2015

Keywords

  • 4,5-Di-isobuty-2(1H)-pyrimidinone
  • 6-Oxo-12-norcytochalasin D
  • Cytochalasins
  • Cytotoxic activity
  • Endophytic fungus
  • Tillandsia usneoides
  • Xylariaceae

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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