Cytotoxic lignans from Larrea tridentata

Joshua D. Lambert, Shengmin Sang, Ann Dougherty, Colby G. Caldwell, Ross O. Meyers, Robert T Dorr, Barbara N. Timmermann

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Six lignans, including the cyclolignan 3,4′-dihydroxy-3′, 4′-dimethoxy-6,7′-cyclolignan, were isolated from the flowering tops of Larrea tridentata. Additionally the flavanone, (S)-4′,5-dihydroxy-7- methoxyflavanone, was isolated for the first time from L. tridentata or any member of the family Zygophyllaceae. All of the compounds were assessed for their growth inhibitory activity against human breast cancer, human colon cancer and human melanoma cell lines. The lignans had IC50 values of 5-60 μM with the linear butane-type lignans being the most potent, and it was found that colon cancer cells were the least sensitive cell type tested. The relative potency of linear butane type lignans against human breast cancer appears to correlate positively with the number of O-methyl groups present on the molecule.

Original languageEnglish (US)
Pages (from-to)811-815
Number of pages5
JournalPhytochemistry
Volume66
Issue number7
DOIs
StatePublished - Apr 2005

Fingerprint

Larrea
Larrea tridentata
Lignans
lignans
Colonic Neoplasms
colorectal neoplasms
breast neoplasms
Flowering Tops
Zygophyllaceae
Cells
Breast Neoplasms
flavanones
melanoma
Human Activities
Inhibitory Concentration 50
inhibitory concentration 50
Melanoma
cell lines
flowering
Cell Line

Keywords

  • Cancer
  • Creosote bush
  • Cytotoxicity
  • Flavanone
  • Larrea tridentata
  • Lignans
  • Zygophyllaceae

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery

Cite this

Lambert, J. D., Sang, S., Dougherty, A., Caldwell, C. G., Meyers, R. O., Dorr, R. T., & Timmermann, B. N. (2005). Cytotoxic lignans from Larrea tridentata. Phytochemistry, 66(7), 811-815. https://doi.org/10.1016/j.phytochem.2005.02.007

Cytotoxic lignans from Larrea tridentata. / Lambert, Joshua D.; Sang, Shengmin; Dougherty, Ann; Caldwell, Colby G.; Meyers, Ross O.; Dorr, Robert T; Timmermann, Barbara N.

In: Phytochemistry, Vol. 66, No. 7, 04.2005, p. 811-815.

Research output: Contribution to journalArticle

Lambert, JD, Sang, S, Dougherty, A, Caldwell, CG, Meyers, RO, Dorr, RT & Timmermann, BN 2005, 'Cytotoxic lignans from Larrea tridentata', Phytochemistry, vol. 66, no. 7, pp. 811-815. https://doi.org/10.1016/j.phytochem.2005.02.007
Lambert JD, Sang S, Dougherty A, Caldwell CG, Meyers RO, Dorr RT et al. Cytotoxic lignans from Larrea tridentata. Phytochemistry. 2005 Apr;66(7):811-815. https://doi.org/10.1016/j.phytochem.2005.02.007
Lambert, Joshua D. ; Sang, Shengmin ; Dougherty, Ann ; Caldwell, Colby G. ; Meyers, Ross O. ; Dorr, Robert T ; Timmermann, Barbara N. / Cytotoxic lignans from Larrea tridentata. In: Phytochemistry. 2005 ; Vol. 66, No. 7. pp. 811-815.
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