CYTOTOXIC T LYMPHOCYTE RECOGNITION OF HYBRID MHC CLASS I MOLECULES

T. Kanda, M. J. Macchi, K. LaPan, M. Darsley, E. Appella, J. A. Frelinger

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We have utilized a group of MHC class I genes produced by in vitro recombination between Dp and Dd to study recognition of MHC class I molecules by cytolytic T cells (CTLs). Both polyclonal allo‐specific and H‐2‐restricted CTLs require that α1 and a2 of the target class I molecule be derived from the same haplotype for efficient killing. By using T‐cell lines we showed that within the bulk population there must exist a fraction of T cells which can recognize epitopes in al or α2. Critical residues for T‐cell recognition have been identified using these chimeric genes.

Original languageEnglish (US)
Pages (from-to)295-305
Number of pages11
JournalInternational Journal of Immunogenetics
Volume15
Issue number5-6
DOIs
StatePublished - Oct 1988
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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