Daphnane diterpenes from wikstroemia monticola: Wikstrotoxins A-D, huratoxin, and excoecariatoxin

Shivanand D. Jolad; Joseph J. Hoffmann; Barbara N. Timmermann; Karl H. Schram; Jack R. Cole; Robert B. Bates; Robert E. Klenck; Michael S. Tempesta

doi:10.1021/np50029a015

Daphnane diterpenes from wikstroemia monticola: Wikstrotoxins A-D, huratoxin, and excoecariatoxin

Shivanand D. Jolad, Joseph J. Hoffmann, Barbara N. Timmermann, Karl H. Schram, Jack R. Cole, Robert B. Bates, Robert E. Klenck, Michael S. Tempesta

Pharmacy Practice and Science

Research output: Contribution to journal › Article

27 Scopus citations

Abstract

An ether extract of Wikstroemia montícola (Thymelaeaceae) yielded, upon further fractionation, a tic-homogeneous mixture. The resolution of this mixture by reversed phase hplc gave six daphnane diterpenes: wikstrotoxins A (1), B (3), C (5), and D (6), huratoxin (2), and excoecariatoxin (4). The identities of wikstrotoxins A-D, which are new, were established by spectral properties. For the first time, 13C-nmr data are given for 2.

Original language	English (US)
Pages (from-to)	675-680
Number of pages	6
Journal	Journal Of Natural Products
Volume	46
Issue number	5
DOIs	https://doi.org/10.1021/np50029a015
State	Published - Sep 1983

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np50029a015

Fingerprint Dive into the research topics of 'Daphnane diterpenes from wikstroemia monticola: Wikstrotoxins A-D, huratoxin, and excoecariatoxin'. Together they form a unique fingerprint.

Cite this

Jolad, S. D., Hoffmann, J. J., Timmermann, B. N., Schram, K. H., Cole, J. R., Bates, R. B., Klenck, R. E., & Tempesta, M. S. (1983). Daphnane diterpenes from wikstroemia monticola: Wikstrotoxins A-D, huratoxin, and excoecariatoxin. Journal Of Natural Products, 46(5), 675-680. https://doi.org/10.1021/np50029a015

Daphnane diterpenes from wikstroemia monticola : Wikstrotoxins A-D, huratoxin, and excoecariatoxin. / Jolad, Shivanand D.; Hoffmann, Joseph J.; Timmermann, Barbara N.; Schram, Karl H.; Cole, Jack R.; Bates, Robert B.; Klenck, Robert E.; Tempesta, Michael S.

In: Journal Of Natural Products, Vol. 46, No. 5, 09.1983, p. 675-680.

Research output: Contribution to journal › Article

@article{3da13eac534b410698527dc2be982e10,

title = "Daphnane diterpenes from wikstroemia monticola: Wikstrotoxins A-D, huratoxin, and excoecariatoxin",

abstract = "An ether extract of Wikstroemia mont{\'i}cola (Thymelaeaceae) yielded, upon further fractionation, a tic-homogeneous mixture. The resolution of this mixture by reversed phase hplc gave six daphnane diterpenes: wikstrotoxins A (1), B (3), C (5), and D (6), huratoxin (2), and excoecariatoxin (4). The identities of wikstrotoxins A-D, which are new, were established by spectral properties. For the first time, 13C-nmr data are given for 2.",

author = "Jolad, {Shivanand D.} and Hoffmann, {Joseph J.} and Timmermann, {Barbara N.} and Schram, {Karl H.} and Cole, {Jack R.} and Bates, {Robert B.} and Klenck, {Robert E.} and Tempesta, {Michael S.}",

year = "1983",

month = sep,

doi = "10.1021/np50029a015",

language = "English (US)",

volume = "46",

pages = "675--680",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - Daphnane diterpenes from wikstroemia monticola

T2 - Wikstrotoxins A-D, huratoxin, and excoecariatoxin

AU - Jolad, Shivanand D.

AU - Hoffmann, Joseph J.

AU - Timmermann, Barbara N.

AU - Schram, Karl H.

AU - Cole, Jack R.

AU - Bates, Robert B.

AU - Klenck, Robert E.

AU - Tempesta, Michael S.

PY - 1983/9

Y1 - 1983/9

N2 - An ether extract of Wikstroemia montícola (Thymelaeaceae) yielded, upon further fractionation, a tic-homogeneous mixture. The resolution of this mixture by reversed phase hplc gave six daphnane diterpenes: wikstrotoxins A (1), B (3), C (5), and D (6), huratoxin (2), and excoecariatoxin (4). The identities of wikstrotoxins A-D, which are new, were established by spectral properties. For the first time, 13C-nmr data are given for 2.

AB - An ether extract of Wikstroemia montícola (Thymelaeaceae) yielded, upon further fractionation, a tic-homogeneous mixture. The resolution of this mixture by reversed phase hplc gave six daphnane diterpenes: wikstrotoxins A (1), B (3), C (5), and D (6), huratoxin (2), and excoecariatoxin (4). The identities of wikstrotoxins A-D, which are new, were established by spectral properties. For the first time, 13C-nmr data are given for 2.

UR - http://www.scopus.com/inward/record.url?scp=0021021758&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021021758&partnerID=8YFLogxK

U2 - 10.1021/np50029a015

DO - 10.1021/np50029a015

M3 - Article

AN - SCOPUS:0021021758

VL - 46

SP - 675

EP - 680

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 5

ER -