Daphnane diterpenes from Wikstroemia monticola

Wikstrotoxins A-D, huratoxin, and excoecariatoxin

Shivanand D. Jolad, Joseph J. Hoffmann, Barbara N. Timmermann, Karl H. Schram, Jack R Cole, Robert B. Bates, Robert E. Klenck, Michael S. Tempesta

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

An ether extract of Wikstroemia monticola (Thymelaeaceae) yielded, upon further fractionation, a tlc-homogeneous mixture. The resolution of this mixture by reversed phase hplc gave six daphnane diterpenes: wikstrotoxins A (1), B (3), C (5), and D (6), huratoxin (2), and excoecatiatoxin (4). The identities of wikstrotoxins A-D, which are new, were established by spectral properties. For the first time, 13C-nmr data are given for 2.

Original languageEnglish (US)
Pages (from-to)675-680
Number of pages6
JournalJournal of Natural Products
Volume46
Issue number5
StatePublished - 1983

Fingerprint

Wikstroemia
Thymelaeaceae
Diterpenes
diterpenoids
Ether
Fractionation
ethers
fractionation
extracts
huratoxin
mezerein

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Jolad, S. D., Hoffmann, J. J., Timmermann, B. N., Schram, K. H., Cole, J. R., Bates, R. B., ... Tempesta, M. S. (1983). Daphnane diterpenes from Wikstroemia monticola: Wikstrotoxins A-D, huratoxin, and excoecariatoxin. Journal of Natural Products, 46(5), 675-680.

Daphnane diterpenes from Wikstroemia monticola : Wikstrotoxins A-D, huratoxin, and excoecariatoxin. / Jolad, Shivanand D.; Hoffmann, Joseph J.; Timmermann, Barbara N.; Schram, Karl H.; Cole, Jack R; Bates, Robert B.; Klenck, Robert E.; Tempesta, Michael S.

In: Journal of Natural Products, Vol. 46, No. 5, 1983, p. 675-680.

Research output: Contribution to journalArticle

Jolad, SD, Hoffmann, JJ, Timmermann, BN, Schram, KH, Cole, JR, Bates, RB, Klenck, RE & Tempesta, MS 1983, 'Daphnane diterpenes from Wikstroemia monticola: Wikstrotoxins A-D, huratoxin, and excoecariatoxin', Journal of Natural Products, vol. 46, no. 5, pp. 675-680.
Jolad, Shivanand D. ; Hoffmann, Joseph J. ; Timmermann, Barbara N. ; Schram, Karl H. ; Cole, Jack R ; Bates, Robert B. ; Klenck, Robert E. ; Tempesta, Michael S. / Daphnane diterpenes from Wikstroemia monticola : Wikstrotoxins A-D, huratoxin, and excoecariatoxin. In: Journal of Natural Products. 1983 ; Vol. 46, No. 5. pp. 675-680.
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AU - Timmermann, Barbara N.

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AU - Cole, Jack R

AU - Bates, Robert B.

AU - Klenck, Robert E.

AU - Tempesta, Michael S.

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