Daphnane diterpenes from wikstroemia monticola: Wikstrotoxins A-D, huratoxin, and excoecariatoxin

Shivanand D. Jolad; Joseph J. Hoffmann; Barbara N. Timmermann; Karl H. Schram; Jack R. Cole; Robert B. Bates; Robert E. Klenck; Michael S. Tempesta

doi:10.1021/np50029a015

Daphnane diterpenes from wikstroemia monticola: Wikstrotoxins A-D, huratoxin, and excoecariatoxin

Shivanand D. Jolad, Joseph J. Hoffmann, Barbara N. Timmermann, Karl H. Schram, Jack R. Cole, Robert B. Bates, Robert E. Klenck, Michael S. Tempesta

Pharmacy Practice and Science

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

An ether extract of Wikstroemia montícola (Thymelaeaceae) yielded, upon further fractionation, a tic-homogeneous mixture. The resolution of this mixture by reversed phase hplc gave six daphnane diterpenes: wikstrotoxins A (1), B (3), C (5), and D (6), huratoxin (2), and excoecariatoxin (4). The identities of wikstrotoxins A-D, which are new, were established by spectral properties. For the first time, 13C-nmr data are given for 2.

Original language	English (US)
Pages (from-to)	675-680
Number of pages	6
Journal	Journal Of Natural Products
Volume	46
Issue number	5
DOIs	https://doi.org/10.1021/np50029a015
State	Published - Sep 1983

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50029a015

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Daphnane diterpenes from wikstroemia monticola : Wikstrotoxins A-D, huratoxin, and excoecariatoxin. / Jolad, Shivanand D.; Hoffmann, Joseph J.; Timmermann, Barbara N.; Schram, Karl H.; Cole, Jack R.; Bates, Robert B.; Klenck, Robert E.; Tempesta, Michael S.

In: Journal Of Natural Products, Vol. 46, No. 5, 09.1983, p. 675-680.

Research output: Contribution to journal › Article › peer-review

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title = "Daphnane diterpenes from wikstroemia monticola: Wikstrotoxins A-D, huratoxin, and excoecariatoxin",

abstract = "An ether extract of Wikstroemia mont{\'i}cola (Thymelaeaceae) yielded, upon further fractionation, a tic-homogeneous mixture. The resolution of this mixture by reversed phase hplc gave six daphnane diterpenes: wikstrotoxins A (1), B (3), C (5), and D (6), huratoxin (2), and excoecariatoxin (4). The identities of wikstrotoxins A-D, which are new, were established by spectral properties. For the first time, 13C-nmr data are given for 2.",

author = "Jolad, {Shivanand D.} and Hoffmann, {Joseph J.} and Timmermann, {Barbara N.} and Schram, {Karl H.} and Cole, {Jack R.} and Bates, {Robert B.} and Klenck, {Robert E.} and Tempesta, {Michael S.}",

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T2 - Wikstrotoxins A-D, huratoxin, and excoecariatoxin

AU - Jolad, Shivanand D.

AU - Hoffmann, Joseph J.

AU - Timmermann, Barbara N.

AU - Schram, Karl H.

AU - Cole, Jack R.

AU - Bates, Robert B.

AU - Klenck, Robert E.

AU - Tempesta, Michael S.

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N2 - An ether extract of Wikstroemia montícola (Thymelaeaceae) yielded, upon further fractionation, a tic-homogeneous mixture. The resolution of this mixture by reversed phase hplc gave six daphnane diterpenes: wikstrotoxins A (1), B (3), C (5), and D (6), huratoxin (2), and excoecariatoxin (4). The identities of wikstrotoxins A-D, which are new, were established by spectral properties. For the first time, 13C-nmr data are given for 2.

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Daphnane diterpenes from wikstroemia monticola: Wikstrotoxins A-D, huratoxin, and excoecariatoxin

Abstract

ASJC Scopus subject areas

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