Daphnane diterpenes from wikstroemia monticola: Wikstrotoxins A-D, huratoxin, and excoecariatoxin

Shivanand D. Jolad, Joseph J. Hoffmann, Barbara N. Timmermann, Karl H. Schram, Jack R. Cole, Robert B. Bates, Robert E. Klenck, Michael S. Tempesta

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

An ether extract of Wikstroemia montícola (Thymelaeaceae) yielded, upon further fractionation, a tic-homogeneous mixture. The resolution of this mixture by reversed phase hplc gave six daphnane diterpenes: wikstrotoxins A (1), B (3), C (5), and D (6), huratoxin (2), and excoecariatoxin (4). The identities of wikstrotoxins A-D, which are new, were established by spectral properties. For the first time, 13C-nmr data are given for 2.

Original languageEnglish (US)
Pages (from-to)675-680
Number of pages6
JournalJournal Of Natural Products
Volume46
Issue number5
DOIs
StatePublished - Sep 1983

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Jolad, S. D., Hoffmann, J. J., Timmermann, B. N., Schram, K. H., Cole, J. R., Bates, R. B., Klenck, R. E., & Tempesta, M. S. (1983). Daphnane diterpenes from wikstroemia monticola: Wikstrotoxins A-D, huratoxin, and excoecariatoxin. Journal Of Natural Products, 46(5), 675-680. https://doi.org/10.1021/np50029a015