DARPA's Big Mechanism program

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Reductionist science produces causal models of small fragments of complicated systems. Causal models of entire systems can be hard to construct because what is known of them is distributed across a vast amount of literature. The Big Mechanism program aims to have machines read the literature and assemble the causal fragments found in individual papers into huge causal models, automatically. The current domain of the program is cell signalling associated with Ras-driven cancers.

Original languageEnglish (US)
Article number045008
JournalPhysical Biology
Issue number4
StatePublished - Jul 1 2015


  • artificial intelligence
  • biocuration
  • information extraction
  • machine reading
  • modeling
  • signaling pathways
  • systems biology

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Molecular Biology
  • Cell Biology


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