Decline in working memory associated with HIV infection

J. C. Stout, D. P. Salmon, N. Butters, M. Taylor, G. Peavy, W. C. Heindel, D. C. Delis, T Lee Ryan, J. H. Atkinson, J. L. Chandler, I. Grant

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

HIV infection has been associated with decline in a number of cognitive functions that are components of 'working memory'. Thus, tests of working memory that require the interaction of these components may be particularly sensitive to cognitive dysfunction that arises from HIV infection. To assess this possibility, working memory was examined in 147 HIV-seropositive (HIV+) and 38 HIV-seronegative (HIV-) males using the Reading Span Test and the Digit Span subtest from the Wechsler Memory Scale-Revised (WMS-R). Speed of information processing, a component of some working memory tasks, was assessed with a version of the Sternberg Memory Scanning task. Results indicated that symptomatic HIV+ subjects were impaired relative to HIV- control subjects on the Reading Span and Digit Span tests. Asymptomatic and mildly symptomatic HIV+ groups exhibited a trend toward impairment on these tests, and on the whole, a greater proportion of HIV+ subjects than HIV- subjects were impaired. The groups did not differ significantly in information processing speed. These results indicate that deficits in working memory are apparent in at least a subset of HIV-infected individuals. These deficits are most apparent in symptomatic HIV+ individuals, but the decline may begin during the asymptomatic phase of infection.

Original languageEnglish (US)
Pages (from-to)1221-1232
Number of pages12
JournalPsychological Medicine
Volume25
Issue number6
StatePublished - 1995
Externally publishedYes

Fingerprint

Short-Term Memory
HIV Infections
HIV
Automatic Data Processing
Reading
Wechsler Scales
Asymptomatic Infections
Cognition

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Stout, J. C., Salmon, D. P., Butters, N., Taylor, M., Peavy, G., Heindel, W. C., ... Grant, I. (1995). Decline in working memory associated with HIV infection. Psychological Medicine, 25(6), 1221-1232.

Decline in working memory associated with HIV infection. / Stout, J. C.; Salmon, D. P.; Butters, N.; Taylor, M.; Peavy, G.; Heindel, W. C.; Delis, D. C.; Ryan, T Lee; Atkinson, J. H.; Chandler, J. L.; Grant, I.

In: Psychological Medicine, Vol. 25, No. 6, 1995, p. 1221-1232.

Research output: Contribution to journalArticle

Stout, JC, Salmon, DP, Butters, N, Taylor, M, Peavy, G, Heindel, WC, Delis, DC, Ryan, TL, Atkinson, JH, Chandler, JL & Grant, I 1995, 'Decline in working memory associated with HIV infection', Psychological Medicine, vol. 25, no. 6, pp. 1221-1232.
Stout JC, Salmon DP, Butters N, Taylor M, Peavy G, Heindel WC et al. Decline in working memory associated with HIV infection. Psychological Medicine. 1995;25(6):1221-1232.
Stout, J. C. ; Salmon, D. P. ; Butters, N. ; Taylor, M. ; Peavy, G. ; Heindel, W. C. ; Delis, D. C. ; Ryan, T Lee ; Atkinson, J. H. ; Chandler, J. L. ; Grant, I. / Decline in working memory associated with HIV infection. In: Psychological Medicine. 1995 ; Vol. 25, No. 6. pp. 1221-1232.
@article{f1697f44446140fbb067042b81683bcc,
title = "Decline in working memory associated with HIV infection",
abstract = "HIV infection has been associated with decline in a number of cognitive functions that are components of 'working memory'. Thus, tests of working memory that require the interaction of these components may be particularly sensitive to cognitive dysfunction that arises from HIV infection. To assess this possibility, working memory was examined in 147 HIV-seropositive (HIV+) and 38 HIV-seronegative (HIV-) males using the Reading Span Test and the Digit Span subtest from the Wechsler Memory Scale-Revised (WMS-R). Speed of information processing, a component of some working memory tasks, was assessed with a version of the Sternberg Memory Scanning task. Results indicated that symptomatic HIV+ subjects were impaired relative to HIV- control subjects on the Reading Span and Digit Span tests. Asymptomatic and mildly symptomatic HIV+ groups exhibited a trend toward impairment on these tests, and on the whole, a greater proportion of HIV+ subjects than HIV- subjects were impaired. The groups did not differ significantly in information processing speed. These results indicate that deficits in working memory are apparent in at least a subset of HIV-infected individuals. These deficits are most apparent in symptomatic HIV+ individuals, but the decline may begin during the asymptomatic phase of infection.",
author = "Stout, {J. C.} and Salmon, {D. P.} and N. Butters and M. Taylor and G. Peavy and Heindel, {W. C.} and Delis, {D. C.} and Ryan, {T Lee} and Atkinson, {J. H.} and Chandler, {J. L.} and I. Grant",
year = "1995",
language = "English (US)",
volume = "25",
pages = "1221--1232",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",
number = "6",

}

TY - JOUR

T1 - Decline in working memory associated with HIV infection

AU - Stout, J. C.

AU - Salmon, D. P.

AU - Butters, N.

AU - Taylor, M.

AU - Peavy, G.

AU - Heindel, W. C.

AU - Delis, D. C.

AU - Ryan, T Lee

AU - Atkinson, J. H.

AU - Chandler, J. L.

AU - Grant, I.

PY - 1995

Y1 - 1995

N2 - HIV infection has been associated with decline in a number of cognitive functions that are components of 'working memory'. Thus, tests of working memory that require the interaction of these components may be particularly sensitive to cognitive dysfunction that arises from HIV infection. To assess this possibility, working memory was examined in 147 HIV-seropositive (HIV+) and 38 HIV-seronegative (HIV-) males using the Reading Span Test and the Digit Span subtest from the Wechsler Memory Scale-Revised (WMS-R). Speed of information processing, a component of some working memory tasks, was assessed with a version of the Sternberg Memory Scanning task. Results indicated that symptomatic HIV+ subjects were impaired relative to HIV- control subjects on the Reading Span and Digit Span tests. Asymptomatic and mildly symptomatic HIV+ groups exhibited a trend toward impairment on these tests, and on the whole, a greater proportion of HIV+ subjects than HIV- subjects were impaired. The groups did not differ significantly in information processing speed. These results indicate that deficits in working memory are apparent in at least a subset of HIV-infected individuals. These deficits are most apparent in symptomatic HIV+ individuals, but the decline may begin during the asymptomatic phase of infection.

AB - HIV infection has been associated with decline in a number of cognitive functions that are components of 'working memory'. Thus, tests of working memory that require the interaction of these components may be particularly sensitive to cognitive dysfunction that arises from HIV infection. To assess this possibility, working memory was examined in 147 HIV-seropositive (HIV+) and 38 HIV-seronegative (HIV-) males using the Reading Span Test and the Digit Span subtest from the Wechsler Memory Scale-Revised (WMS-R). Speed of information processing, a component of some working memory tasks, was assessed with a version of the Sternberg Memory Scanning task. Results indicated that symptomatic HIV+ subjects were impaired relative to HIV- control subjects on the Reading Span and Digit Span tests. Asymptomatic and mildly symptomatic HIV+ groups exhibited a trend toward impairment on these tests, and on the whole, a greater proportion of HIV+ subjects than HIV- subjects were impaired. The groups did not differ significantly in information processing speed. These results indicate that deficits in working memory are apparent in at least a subset of HIV-infected individuals. These deficits are most apparent in symptomatic HIV+ individuals, but the decline may begin during the asymptomatic phase of infection.

UR - http://www.scopus.com/inward/record.url?scp=0028829538&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028829538&partnerID=8YFLogxK

M3 - Article

C2 - 8637952

AN - SCOPUS:0028829538

VL - 25

SP - 1221

EP - 1232

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 6

ER -