Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers

Ruogang Zhao, Thomas Boudou, Wei Gang Wang, Christopher S. Chen, Daniel H. Reich

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

A novel bio-magnetomechanical microtissue system is described for magnetic actuation of arrays of 3D microtissues using microcantilevers. This system enables both in situ measurements of fundamental mechanical properties of engineered tissue, such as contractility and stiffness, as well as dynamic stimulation of the microtissues. Using this system, cell and extracellular matrix contributions to the tissue mechanical properties are decoupled for the first time under both static and dynamic loading conditions.

Original languageEnglish (US)
Pages (from-to)1699-1705
Number of pages7
JournalAdvanced Materials
Volume25
Issue number12
DOIs
StatePublished - Mar 25 2013
Externally publishedYes

Keywords

  • cell contractility
  • engineered microtissue
  • fibroblast populated collagen matrix
  • magnetic actuation
  • tissue stiffness

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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