Deep Brain Stimulation for the Treatment of Epilepsy

Circuits, Targets, and Trials

Nealen G. Laxpati, Willard Kasoff, Robert E. Gross

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Deep brain stimulation (DBS) has proven remarkably safe and effective in the treatment of movement disorders. As a result, it is being increasingly applied to a range of neurologic and psychiatric disorders, including medically refractory epilepsy. This review will examine the use of DBS in epilepsy, including known targets, mechanisms of neuromodulation and seizure control, published clinical evidence, and novel technologies. Cortical and deep neuromodulation for epilepsy has a long experimental history, but only recently have better understanding of epileptogenic networks, precise stereotactic techniques, and rigorous trial design combined to improve the quality of available evidence and make DBS a viable treatment option. Nonetheless, underlying mechanisms, anatomical targets, and stimulation parameters remain areas of active investigation.

Original languageEnglish (US)
Pages (from-to)508-526
Number of pages19
JournalNeurotherapeutics
Volume11
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Deep Brain Stimulation
Epilepsy
Stereotaxic Techniques
Movement Disorders
Nervous System Diseases
Psychiatry
Seizures
Therapeutics
History
Technology

Keywords

  • anterior nucleus
  • centromedian nucleus
  • deep brain stimulation
  • Epilepsy
  • neuromodulation
  • SANTE

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Pharmacology
  • Medicine(all)

Cite this

Deep Brain Stimulation for the Treatment of Epilepsy : Circuits, Targets, and Trials. / Laxpati, Nealen G.; Kasoff, Willard; Gross, Robert E.

In: Neurotherapeutics, Vol. 11, No. 3, 2014, p. 508-526.

Research output: Contribution to journalArticle

Laxpati, Nealen G. ; Kasoff, Willard ; Gross, Robert E. / Deep Brain Stimulation for the Treatment of Epilepsy : Circuits, Targets, and Trials. In: Neurotherapeutics. 2014 ; Vol. 11, No. 3. pp. 508-526.
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