Deep homology of arthropod central complex and vertebrate basal ganglia

Research output: Contribution to journalReview article

183 Scopus citations

Abstract

The arthropod central complex and vertebrate basal ganglia derive from embryonic basal forebrain lineages that are specified by an evolutionarily conserved genetic program leading to interconnected neuropils and nuclei that populate the midline of the forebrain-midbrain boundary region. In the substructures of both the central complex and basal ganglia, network connectivity and neuronal activity mediate control mechanisms in which inhibitory (GABAergic) and modulatory (dopaminergic) circuits facilitate the regulation and release of adaptive behaviors. Both basal ganglia and central complex dysfunction result in behavioral defects including motor abnormalities, impaired memory formation, attention deficits, affective disorders, and sleep disturbances. The observed multitude of similarities suggests deep homology of arthropod central complex and vertebrate basal ganglia circuitries underlying the selection and maintenance of behavioral actions.

Original languageEnglish (US)
Pages (from-to)157-161
Number of pages5
JournalScience
Volume340
Issue number6129
DOIs
StatePublished - Apr 12 2013

ASJC Scopus subject areas

  • General

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