Defining the role of polyamines in colon carcinogenesis using mouse models

Natalia Ignatenko, Eugene Gerner, David Besselsen

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Genetics and diet are both considered important risk determinants for colorectal cancer, a leading cause of death in the US and worldwide. Genetically engineered mouse (GEM) models have made a significant contribution to the characterization of colorectal cancer risk factors. Reliable, reproducible, and clinically relevant animal models help in the identification of the molecular events associated with disease progression and in the development of effictive treatment strategies. This review is focused on the use of mouse models for studying the role of polyamines in colon carcinogenesis. We describe how the available mouse models of colon cancer such as the multiple intestinal neoplasia (Min) mice and knockout genetic models facilitate understanding of the role of polyamines in colon carcinogenesis and help in the development of a rational strategy for colon cancer chemoprevention.

Original languageEnglish (US)
Article number10
JournalJournal of Carcinogenesis
Volume10
DOIs
StatePublished - 2011

Keywords

  • Apc
  • DFMO
  • NSAIDs
  • SLC3A2
  • mouse models
  • polyamines

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Health, Toxicology and Mutagenesis

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