Deformationally dependent fluid transport properties of porcine coronary arteries based on location in the coronary vasculature

Joseph T. Keyes, Danielle R. Lockwood, Bruce R. Simon, Jonathan P Vande Geest

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: Understanding coronary artery mass transport allows researchers to better comprehend how drugs or proteins move through, and deposit into, the arterial wall. Characterizing how the convective component of transport changes based on arterial location could be useful to better understand how molecules distribute in different locations in the coronary vasculature. Methods and results: We measured the mechanical properties and wall fluid flux transport properties of de-endothelialized (similar to post-stenting or angioplasty) left anterior descending (LADC) and right (RC) porcine coronary arteries along their arterial lengths. Multiphoton microscopy was used to determine microstructural differences. Proximal LADC regions had a higher circumferential stiffness than all other regions. Permeability decreased by 198% in the LADC distal region compared to other LADC regions. The RC artery showed a decrease of 46.9% from the proximal to middle region, and 51.7% from the middle to distal regions. The porosity increased in the intima between pressure states, without differences through the remainder of the arterial thickness. Conclusions: We showed that the permeabilities and mechanical properties do vary in the coronary vasculature. With variations in mechanical properties, overexpansion of stents can occur more easily while variations in permeability may lead to altered transport based on location.

Original languageEnglish (US)
Pages (from-to)296-306
Number of pages11
JournalJournal of the Mechanical Behavior of Biomedical Materials
Volume17
DOIs
StatePublished - 2012

Fingerprint

Transport properties
Mechanical properties
Fluids
Stents
Microscopic examination
Mass transfer
Deposits
Porosity
Stiffness
Fluxes
Proteins
Molecules
Pharmaceutical Preparations

Keywords

  • Coronary
  • Mechanical
  • Permeability
  • Porohyperelastic
  • Transport

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials

Cite this

Deformationally dependent fluid transport properties of porcine coronary arteries based on location in the coronary vasculature. / Keyes, Joseph T.; Lockwood, Danielle R.; Simon, Bruce R.; Vande Geest, Jonathan P.

In: Journal of the Mechanical Behavior of Biomedical Materials, Vol. 17, 2012, p. 296-306.

Research output: Contribution to journalArticle

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