Degradation kinetics and mechanism of RH1, a new anti-tumor agent: A technical note

Neera Jain, Stephen G. Machatha, S. Esmail Tabibi, Samuel H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

Abstract

The degradation of RH1 in aqueous solution is found to be both acid and base catalyzed. The maximum stability is obtained in neutral pH but still degrades by 10% (t90) after just 1 week. The stability profile at pH 5 was done, and 4 major degradation products were observed in acid solutions. LC-MS was performed and the molecular weights determined, from which a degradation mechanism was proposed. Degradation products I, II, and III form 2 isomers each depending on which aziridine group is hydrolyzed. No significant effect of light or the presence of antioxidants was observed, indicating that photodegradation and oxidation are not likely degradation reactions.

Original languageEnglish (US)
Article number16
JournalAAPS PharmSciTech
Volume8
Issue number1
DOIs
StatePublished - Mar 2 2007

Keywords

  • Degradation
  • Mechanism
  • RH1
  • Solubility
  • Stability

ASJC Scopus subject areas

  • Pharmaceutical Science

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