Degradation kinetics of 4-dedimethylamino sancycline, a new anti-tumor agent, in aqueous solutions

Sirirat Pinsuwan, Fernando A. Alvarez-Núñez, Esmail S. Tabibi, Samuel H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The kinetics of degradation of the new anti-tumor drug, 4-dedimethylamino sancycline (col-3) in aqueous solution at 25(o)C were investigated by high-pressure liquid chromatography (HPLC) over the pH-range of 2-10. The influences of pH, buffer concentration, light, temperature, and some additives on the degradation rate were studied. The degradation of col-3 was found to follow first order kinetics. A rate expression covering the degradation of the various ionic forms of the drug was derived and shown to account for the shape of the experimental pH-rate profile. Under basic conditions, the degradation of col-3 involves oxidation, which is catalyzed by metal ions and inhibited by EDTA and Sodium bisulfite. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)31-40
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume181
Issue number1
DOIs
StatePublished - Apr 20 1999

Keywords

  • 4-Dedimethylamino sancycline
  • Anti-tumor agent
  • Aqueous solutions

ASJC Scopus subject areas

  • Pharmaceutical Science

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