Dehydroepiandrosterone (DHEA) sulfate prevents reduction in tissue vitamin E and increased lipid peroxidation due to murine retrovirus infection of aged mice

M. Araghi-Niknam, S. K. Ardestani, M. Molitor, P. Inserra, C. D. Eskelson, Ronald R Watson

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19 Citations (Scopus)

Abstract

Dietary effects of dehydroepiandrosterone sulfate (DHEAS) supplementation on tissue antioxidants and lipids were investigated in retrovirus infected mice. DHEA is a powerful antioxidant and immunomodulator whose production declines with age. For this study, twenty-four female, 15- month-old C57BL/6 mice were left uninfected while twenty-four were infected with LP-BM5 murine leukemia virus, causing murine AIDS. The retroviral infection caused immune dysfunction and loss of hepatic and cardiac vitamins E and A, resulting in increased lipid peroxides. Treatment with DHEAS at 0.01 or 0.005% in drinking water for 10 weeks post-infection significantly (P < 0.05) lowered lipid peroxidation in both heart and liver tissues. Treatment with DHEAS also largely prevented loss of the antioxidants, such as vitamin E and A, and prevented loss of phospholipid in the hearts and livers of the old uninfected as well as infected mice. This study suggests that DHEAS supplementation reduces damage associated with elevated oxidation due to aging and retrovirus infection.

Original languageEnglish (US)
Pages (from-to)210-217
Number of pages8
JournalProceedings of the Society for Experimental Biology and Medicine
Volume218
Issue number3
StatePublished - Jul 1998

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Retroviridae Infections
Dehydroepiandrosterone Sulfate
Vitamin E
Lipid Peroxidation
Tissue
Lipids
Antioxidants
Vitamin A
Liver
Murine Acquired Immunodeficiency Syndrome
Murine Leukemia Viruses
Dehydroepiandrosterone
Lipid Peroxides
Immunologic Factors
Retroviridae
Infection
Inbred C57BL Mouse
Viruses
Drinking Water
Phospholipids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dehydroepiandrosterone (DHEA) sulfate prevents reduction in tissue vitamin E and increased lipid peroxidation due to murine retrovirus infection of aged mice. / Araghi-Niknam, M.; Ardestani, S. K.; Molitor, M.; Inserra, P.; Eskelson, C. D.; Watson, Ronald R.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 218, No. 3, 07.1998, p. 210-217.

Research output: Contribution to journalArticle

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