Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase

Philip L. Cohen, Roberto Caricchio, Valsamma Abraham, Todd D. Camenisch, J. Charles Jennette, Robert A.S. Roubey, H. Shelton Earp, Glenn Matsushima, Elizabeth A. Reap

Research output: Contribution to journalArticlepeer-review

475 Scopus citations

Abstract

Mice lacking the membrane tyrosine kinase c-mer have been shown to have altered macrophage cytokine production and defective phagocytosis of apoptotic cells despite normal phagocytosis of other particles. We show here that c-mer- deficient mice have impaired clearance of infused apoptotic cells and that they develop progressive lupus-like autoimmunity, with anti-bodies to chromatin, DNA, and IgG. The autoimmunity appears to be driven by endogenous antigens, with little polyclonal B cell activation. These mice should be an excellent model for studying the role of apoptotic debris as an immunogenic stimulus for systemic autoimmunity.

Original languageEnglish (US)
Pages (from-to)135-140
Number of pages6
JournalJournal of Experimental Medicine
Volume196
Issue number1
DOIs
StatePublished - Jul 1 2002

Keywords

  • Apoptosis
  • Autoimmunity
  • Lupus Erythematosus, systemic
  • Macrophages
  • Phagocytosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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