Delayed sleep phase cases and controls

Daniel F. Kripke, Katharine M. Rex, Sonia Ancoli-Israel, Caroline M. Nievergelt, Walt Klimecki, John R. Kelsoe

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Background: Delayed sleep phase disorder (DSPD) is a condition in which patients have difficulty falling asleep before the early morning hours and commonly have trouble awakening before late morning or even early afternoon. Several studies have suggested that variations in habitual bedtime are 40-50% heritable. Methods: We recruited a case series of 205 participants, along with 221 controls (DSPD-C) with normal sleep, roughly matched for age, gender, and ancestry. A representative sample of San Diego adults recruited some years before was already available to confirm the control group. Both DSPD and DSPD-C provided blood or saliva samples for DNA and completed extensive questionnaires about sleep habits, sleep history, family history, sleep quality, morningness-eveningness traits, depression, mania, and seasonality of symptoms. The DSPD group wore wrist actigraphs for a median of 13.2 days. The representative sample collected previously had undergone actigraphic recordings, from which 48 hours of data were generally available. Results: The DSPD and DSPD-C samples showed almost no overlap on morningness-eveningness scores. DSPD cases went to bed and arose about 3 hours later than the DSPD-C and the representative sample. DSPD cases reported more difficulties with sleep, poorer sleep quality, and more depression, but there was no significant difference in a history of mania. DSPD cases reported more family history of late bedtimes, but female DSPD reported that their fathers' bedtimes were later than the fathers of male DSPD. Conclusion: These results indicate a DSPD phenotype is familial and associated with unipolar depression.

Original languageEnglish (US)
Article number6
JournalJournal of Circadian Rhythms
Volume6
DOIs
StatePublished - Apr 29 2008

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems

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    Kripke, D. F., Rex, K. M., Ancoli-Israel, S., Nievergelt, C. M., Klimecki, W., & Kelsoe, J. R. (2008). Delayed sleep phase cases and controls. Journal of Circadian Rhythms, 6, [6]. https://doi.org/10.1186/1740-3391-6-6