Delayed sleep phase cases and controls

Daniel F. Kripke, Katharine M. Rex, Sonia Ancoli-Israel, Caroline M. Nievergelt, Walter Klimecki, John R. Kelsoe

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: Delayed sleep phase disorder (DSPD) is a condition in which patients have difficulty falling asleep before the early morning hours and commonly have trouble awakening before late morning or even early afternoon. Several studies have suggested that variations in habitual bedtime are 40-50% heritable. Methods: We recruited a case series of 205 participants, along with 221 controls (DSPD-C) with normal sleep, roughly matched for age, gender, and ancestry. A representative sample of San Diego adults recruited some years before was already available to confirm the control group. Both DSPD and DSPD-C provided blood or saliva samples for DNA and completed extensive questionnaires about sleep habits, sleep history, family history, sleep quality, morningness-eveningness traits, depression, mania, and seasonality of symptoms. The DSPD group wore wrist actigraphs for a median of 13.2 days. The representative sample collected previously had undergone actigraphic recordings, from which 48 hours of data were generally available. Results: The DSPD and DSPD-C samples showed almost no overlap on morningness-eveningness scores. DSPD cases went to bed and arose about 3 hours later than the DSPD-C and the representative sample. DSPD cases reported more difficulties with sleep, poorer sleep quality, and more depression, but there was no significant difference in a history of mania. DSPD cases reported more family history of late bedtimes, but female DSPD reported that their fathers' bedtimes were later than the fathers of male DSPD. Conclusion: These results indicate a DSPD phenotype is familial and associated with unipolar depression.

Original languageEnglish (US)
Article number6
JournalJournal of Circadian Rhythms
Volume6
DOIs
StatePublished - Apr 29 2008

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Sleep
Sleep Wake Disorders
Bipolar Disorder
Fathers
Depression
Depressive Disorder
Wrist
Saliva
Habits
Phenotype
Control Groups

ASJC Scopus subject areas

  • Physiology

Cite this

Kripke, D. F., Rex, K. M., Ancoli-Israel, S., Nievergelt, C. M., Klimecki, W., & Kelsoe, J. R. (2008). Delayed sleep phase cases and controls. Journal of Circadian Rhythms, 6, [6]. https://doi.org/10.1186/1740-3391-6-6

Delayed sleep phase cases and controls. / Kripke, Daniel F.; Rex, Katharine M.; Ancoli-Israel, Sonia; Nievergelt, Caroline M.; Klimecki, Walter; Kelsoe, John R.

In: Journal of Circadian Rhythms, Vol. 6, 6, 29.04.2008.

Research output: Contribution to journalArticle

Kripke, DF, Rex, KM, Ancoli-Israel, S, Nievergelt, CM, Klimecki, W & Kelsoe, JR 2008, 'Delayed sleep phase cases and controls', Journal of Circadian Rhythms, vol. 6, 6. https://doi.org/10.1186/1740-3391-6-6
Kripke DF, Rex KM, Ancoli-Israel S, Nievergelt CM, Klimecki W, Kelsoe JR. Delayed sleep phase cases and controls. Journal of Circadian Rhythms. 2008 Apr 29;6. 6. https://doi.org/10.1186/1740-3391-6-6
Kripke, Daniel F. ; Rex, Katharine M. ; Ancoli-Israel, Sonia ; Nievergelt, Caroline M. ; Klimecki, Walter ; Kelsoe, John R. / Delayed sleep phase cases and controls. In: Journal of Circadian Rhythms. 2008 ; Vol. 6.
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