Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract

Gary V. Martinez, Suryakiran Navath, Kamini Sewda, Venkataramanarao Rao, Parastou Foroutan, Ramesh Alleti, Valerie E. Moberg, Ali M. Ahad, Domenico Coppola, Mark C. Lloyd, Robert J. Gillies, David L. Morse, Eugene A. Mash

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47 h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.

Original languageEnglish (US)
Pages (from-to)2061-2064
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number7
DOIs
StatePublished - Apr 1 2013

Keywords

  • Contrast agent
  • DOTA
  • Gadolinium
  • Gastrointestinal tract
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Martinez, G. V., Navath, S., Sewda, K., Rao, V., Foroutan, P., Alleti, R., Moberg, V. E., Ahad, A. M., Coppola, D., Lloyd, M. C., Gillies, R. J., Morse, D. L., & Mash, E. A. (2013). Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract. Bioorganic and Medicinal Chemistry Letters, 23(7), 2061-2064. https://doi.org/10.1016/j.bmcl.2013.02.008