Abstract
Insect motoneurons display dramatic dendritic plasticity during metamorphosis. Many larval motoneurons survive to adulthood but undergo dendritic regression and outgrowth as they are incorporated into developing circuits. This study explores the dendritic remodeling and development of Drosophila motoneurons MN1-MN5, which innervate indirect flight muscles of the adult. MN1-MN5 are persistent larval neurons exhibiting two distinct metamorphic histories. MN1-MN4 are born in the embryo, innervate larval muscles, and undergo dendritic regression and regrowth during metamorphosis. MN5, which was identified through a combination of intracellular dye injection and retrograde staining at all stages, is also born embryonically but remains developmentally arrested until the onset of metamorphosis. In the larva, MN5 lacks dendrites, and its axon stops in the mesothoracic nerve without innervating a target muscle. It is dye coupled to the peripherally synapsing interneuron, which will become part of the giant fiber escape circuit of the adult fly. During pupal development, MN5 undergoes de novo dendritic growth and extension of its axon to innervate the developing target muscle. Its unique developmental history and identifiability make MN5 well suited for the study of dendritic growth using genetic and neurophysiological approaches.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4906-4917 |
| Number of pages | 12 |
| Journal | Journal of Neuroscience |
| Volume | 22 |
| Issue number | 12 |
| State | Published - Jun 15 2002 |
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Keywords
- CNS
- Dendrite
- Dendritic plasticity
- Indirect flight muscles
- Insect
- Motor neuron
- Spine
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Dendritic Remodeling and Growth of Motoneurons during Metamorphosis of Drosophila melanogaster. / Consoulas, Christos; Restifo, Linda L; Levine, Richard B.
In: Journal of Neuroscience, Vol. 22, No. 12, 15.06.2002, p. 4906-4917.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dendritic Remodeling and Growth of Motoneurons during Metamorphosis of Drosophila melanogaster
AU - Consoulas, Christos
AU - Restifo, Linda L
AU - Levine, Richard B
PY - 2002/6/15
Y1 - 2002/6/15
N2 - Insect motoneurons display dramatic dendritic plasticity during metamorphosis. Many larval motoneurons survive to adulthood but undergo dendritic regression and outgrowth as they are incorporated into developing circuits. This study explores the dendritic remodeling and development of Drosophila motoneurons MN1-MN5, which innervate indirect flight muscles of the adult. MN1-MN5 are persistent larval neurons exhibiting two distinct metamorphic histories. MN1-MN4 are born in the embryo, innervate larval muscles, and undergo dendritic regression and regrowth during metamorphosis. MN5, which was identified through a combination of intracellular dye injection and retrograde staining at all stages, is also born embryonically but remains developmentally arrested until the onset of metamorphosis. In the larva, MN5 lacks dendrites, and its axon stops in the mesothoracic nerve without innervating a target muscle. It is dye coupled to the peripherally synapsing interneuron, which will become part of the giant fiber escape circuit of the adult fly. During pupal development, MN5 undergoes de novo dendritic growth and extension of its axon to innervate the developing target muscle. Its unique developmental history and identifiability make MN5 well suited for the study of dendritic growth using genetic and neurophysiological approaches.
AB - Insect motoneurons display dramatic dendritic plasticity during metamorphosis. Many larval motoneurons survive to adulthood but undergo dendritic regression and outgrowth as they are incorporated into developing circuits. This study explores the dendritic remodeling and development of Drosophila motoneurons MN1-MN5, which innervate indirect flight muscles of the adult. MN1-MN5 are persistent larval neurons exhibiting two distinct metamorphic histories. MN1-MN4 are born in the embryo, innervate larval muscles, and undergo dendritic regression and regrowth during metamorphosis. MN5, which was identified through a combination of intracellular dye injection and retrograde staining at all stages, is also born embryonically but remains developmentally arrested until the onset of metamorphosis. In the larva, MN5 lacks dendrites, and its axon stops in the mesothoracic nerve without innervating a target muscle. It is dye coupled to the peripherally synapsing interneuron, which will become part of the giant fiber escape circuit of the adult fly. During pupal development, MN5 undergoes de novo dendritic growth and extension of its axon to innervate the developing target muscle. Its unique developmental history and identifiability make MN5 well suited for the study of dendritic growth using genetic and neurophysiological approaches.
KW - CNS
KW - Dendrite
KW - Dendritic plasticity
KW - Indirect flight muscles
KW - Insect
KW - Motor neuron
KW - Spine
UR - http://www.scopus.com/inward/record.url?scp=0037096407&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037096407&partnerID=8YFLogxK
M3 - Article
C2 - 12077188
AN - SCOPUS:0037096407
VL - 22
SP - 4906
EP - 4917
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 12
ER -