Dendritic vacuolization in the central nervous system of rats after long-term voluntary consumption of ethanol

Barry Goldstein, David S. Maxwell, Gaylord Ellison, Ronald P. Hammer

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Adult male rats were housed in a colony environment for six months, with ad lib access to anise-flavored 10% ethanol in water. Animals were then removed from the colony, and their consumption of alcohol during a period in isolated housing was measured. Individual rats were scored as high, moderate, and low consumers. Animals from each scoring category were killed for light and electron microscopic study of central nervous system tissue. High consumers frequently displayed varicose distortions of the dendritic profiles, with internal membranous vesicles. Such abnormalities were rarely found in dendrites of low-ethanol-consuming colony mates. The dendritic vacuoles often appeared empty and membrane-limited. Some vacuoles contained membranous inclusions. Dendrites which displayed electron-luccnt cavities without membranous limits or contents were also found. Some invaginations of dendritic membranes were identified. The possible sequential relationship between these forms of dendritic alterations could not be determined. Some neuron cell bodies displayed vacuolar inclusions as well. Dendritic and somatic abnormalities were found in cerebral and cerebellar cortices, hippocampus, mammillary bodies, and the periaqueductal gray matter of the brain stem.

Original languageEnglish (US)
Pages (from-to)579-589
Number of pages11
JournalJournal of Neuropathology and Experimental Neurology
Volume42
Issue number5
DOIs
StatePublished - Sep 1983
Externally publishedYes

Keywords

  • Alcohol
  • Alcoholism
  • Animal models
  • Dendrites
  • Varicosities
  • Vascuoles

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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