Denervation of transplanted porcine lung causes airway obstruction

Charles E. Hobson, W. Gerald Teague, Curtis G. Tribble, Stacey E. Mills, Barry Chan, Jon Agee, Terry L. Flanagan, Irving L. Kron

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Lung transplantation can be complicated by a form of small airway obstruction known as bronchiolitis obliterans. We tested the hypothesis that lung denervation causes small airway obstruction in young pigs (10 ± 1 weeks). Control pigs had an innervated native lobe, and study pigs had either a denervated native lobe or a denervated transplant lobe. Transplanted pigs received standard immunosuppression. At 10 weeks we measured isolated left lobe pulmonary mechanics. Dynamic resistance in both study groups was significantly higher than in the lobectomy group, whereas dynamic compliance in both study groups was significantly lower than in the lobectomy group. No significant difference in resistance or compliance was noted between the transplant and reimplant groups. Histologic changes consistent with rejection were noted in the transplant lobes. We conclude that the small airway obstruction noted in this model is due to operative denervation rather than to immunosuppression or rejection.

Original languageEnglish (US)
Pages (from-to)1295-1299
Number of pages5
JournalThe Annals of Thoracic Surgery
Volume52
Issue number6
DOIs
StatePublished - Dec 1991
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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