Dentate gyrus and CA1 ensemble activity during spatial reference frame shifts in the presence and absence of visual input

Katalin M Gothard, Kari L. Hoffman, Francesco P. Battaglia, Bruce L. McNaughton

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

In rats shuttling between a variably placed landmark of origin and a fixed goal, place fields of hippocampal CA1 cells encode location in two spatial reference frames. On the initial part of the outbound journey, place fields encode location with respect to the origin while on the final segment, place fields are aligned with the goal (Gothard et al., 1996b). An abrupt switch of reference frame can be induced experimentally by shortening the distance between the origin and the goal. Two linked hypotheses concerning this effect were addressed: (1) that the persistent, landmark-referenced firing results from some internal dynamic process (e.g., path integration or "momentum") and is not a result of maintained sensory input from the landmark of origin; and (2) that this hypothetical process is generated by connections either within CA3 or between CA3 and CA1, in which case the effect might be absent from the dentate gyrus. Neuronal ensemble recordings were made simultaneously from CA1 and the dentate gyrus as rats shuttled on a linear track between a variably located box and a goal, under light or dark conditions. The box-referenced firing persisted significantly longer in the dark in both hippocampal subfields, suggesting a competitive interaction between an internal dynamic process and external sensory cues. The similarity between reference frame transitions in the dentate gyrus and the CA1 region suggests that this process probably occurs before CA3, possibly in the entorhinal cortex or subiculum.

Original languageEnglish (US)
Pages (from-to)7284-7292
Number of pages9
JournalJournal of Neuroscience
Volume21
Issue number18
StatePublished - Sep 15 2001
Externally publishedYes

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Dentate Gyrus
Entorhinal Cortex
Cues
Hippocampus
Light

Keywords

  • Granule cells
  • Multisite recording
  • Navigation
  • Neural ensembles
  • Path integration
  • Population vector
  • Spatial memory

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dentate gyrus and CA1 ensemble activity during spatial reference frame shifts in the presence and absence of visual input. / Gothard, Katalin M; Hoffman, Kari L.; Battaglia, Francesco P.; McNaughton, Bruce L.

In: Journal of Neuroscience, Vol. 21, No. 18, 15.09.2001, p. 7284-7292.

Research output: Contribution to journalArticle

Gothard, Katalin M ; Hoffman, Kari L. ; Battaglia, Francesco P. ; McNaughton, Bruce L. / Dentate gyrus and CA1 ensemble activity during spatial reference frame shifts in the presence and absence of visual input. In: Journal of Neuroscience. 2001 ; Vol. 21, No. 18. pp. 7284-7292.
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