Abstract
Inhaled particle deposition sites must be identified to effectively treat human airway diseases. We have determined distribution patterns of a selected aeroallergen, ragweed pollen, among human extrathoracic (ET i e., oro-nasopharyngeal) regions and the lung. A predictive model validated by inhalation exposure data from human subjects was utilized. Deposition locations were .primarily functions of 1. ragweed particle parameters (size: 14-20 µm, shape: spherical, and density: 1.14 g cm-3) and 2. mode of breathing. In the general population, two styles of inhalation are prevalent: normal augmentors (NAs), and mouth breathers (MBs), their clinical definitions are based on intra-ET airflow divisions. For a NA-mode breathing, sedentary (10 L m-1) adult, 88% of inhaled ragweed pollen was removed by the ET compartment and 7% collected within the lung. For a MB. the respective deposition efficiencies were 68% and 25%. To apply the model, we used a daily springtime ragweed pollen concentration of 300 grains m-3 and an exposure time of 0.5 hour to calculate actual doses for the respiratory system. Under the stipulated conditions, a MB would inhale 45 pollen grains per day and 8 would be deposited in the lung; the value is 3 grains for a NA. Frequently, individuals with impaired respiratory functions are MBs in whom such pollen deposits are likely contributors to ainway disease.
| Original language | English (US) |
|---|---|
| Article number | A018 |
| Pages (from-to) | 82-86 |
| Number of pages | 5 |
| Journal | Grana |
| Volume | 30 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1991 |
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ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Plant Science
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Deposition patterns of ragweed pollen in the human respiratory tract. / Martonen, T. B.; O'Rourke, Mary Kay.
In: Grana, Vol. 30, No. 1, A018, 1991, p. 82-86.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Deposition patterns of ragweed pollen in the human respiratory tract
AU - Martonen, T. B.
AU - O'Rourke, Mary Kay
PY - 1991
Y1 - 1991
N2 - Inhaled particle deposition sites must be identified to effectively treat human airway diseases. We have determined distribution patterns of a selected aeroallergen, ragweed pollen, among human extrathoracic (ET i e., oro-nasopharyngeal) regions and the lung. A predictive model validated by inhalation exposure data from human subjects was utilized. Deposition locations were .primarily functions of 1. ragweed particle parameters (size: 14-20 µm, shape: spherical, and density: 1.14 g cm-3) and 2. mode of breathing. In the general population, two styles of inhalation are prevalent: normal augmentors (NAs), and mouth breathers (MBs), their clinical definitions are based on intra-ET airflow divisions. For a NA-mode breathing, sedentary (10 L m-1) adult, 88% of inhaled ragweed pollen was removed by the ET compartment and 7% collected within the lung. For a MB. the respective deposition efficiencies were 68% and 25%. To apply the model, we used a daily springtime ragweed pollen concentration of 300 grains m-3 and an exposure time of 0.5 hour to calculate actual doses for the respiratory system. Under the stipulated conditions, a MB would inhale 45 pollen grains per day and 8 would be deposited in the lung; the value is 3 grains for a NA. Frequently, individuals with impaired respiratory functions are MBs in whom such pollen deposits are likely contributors to ainway disease.
AB - Inhaled particle deposition sites must be identified to effectively treat human airway diseases. We have determined distribution patterns of a selected aeroallergen, ragweed pollen, among human extrathoracic (ET i e., oro-nasopharyngeal) regions and the lung. A predictive model validated by inhalation exposure data from human subjects was utilized. Deposition locations were .primarily functions of 1. ragweed particle parameters (size: 14-20 µm, shape: spherical, and density: 1.14 g cm-3) and 2. mode of breathing. In the general population, two styles of inhalation are prevalent: normal augmentors (NAs), and mouth breathers (MBs), their clinical definitions are based on intra-ET airflow divisions. For a NA-mode breathing, sedentary (10 L m-1) adult, 88% of inhaled ragweed pollen was removed by the ET compartment and 7% collected within the lung. For a MB. the respective deposition efficiencies were 68% and 25%. To apply the model, we used a daily springtime ragweed pollen concentration of 300 grains m-3 and an exposure time of 0.5 hour to calculate actual doses for the respiratory system. Under the stipulated conditions, a MB would inhale 45 pollen grains per day and 8 would be deposited in the lung; the value is 3 grains for a NA. Frequently, individuals with impaired respiratory functions are MBs in whom such pollen deposits are likely contributors to ainway disease.
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U2 - 10.1080/00173139109427776
DO - 10.1080/00173139109427776
M3 - Article
VL - 30
SP - 82
EP - 86
JO - Grana
JF - Grana
SN - 0017-3134
IS - 1
M1 - A018
ER -