Depressed mood and lateralized prefrontal activity during a Stroop task in adolescent children

William Killgore, Staci A. Gruber, Deborah A. Yurgelun-Todd

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Negative affective style and depressive disorders share a common pattern of brain activation asymmetry in adults, characterized by reduced left relative to right prefrontal activation. It is not clear whether a similar pattern of asymmetry is related to depressive mood state during the period of adolescence, an important stage of emotional and brain development. We correlated Beck Depression Inventory (BDI) scores from 16 adolescents with prefrontal, anterior cingulate, and amygdala activity during functional magnetic resonance imaging (FMRI) of the Stroop Interference task. Depressed mood correlated positively with activity in the left dorsolateral prefrontal cortex (DLPFC) and anterior cingulate gyrus, and negatively with activity in the right DLPFC. When interpreted from a compensatory recruitment perspective, findings suggest that affective lateralization in adolescents is consistent with that seen in adulthood.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalNeuroscience Letters
Volume416
Issue number1
DOIs
StatePublished - Apr 6 2007
Externally publishedYes

Fingerprint

Gyrus Cinguli
Prefrontal Cortex
Brain
Depressive Disorder
Amygdala
Mood Disorders
Magnetic Resonance Imaging
Depression
Equipment and Supplies

Keywords

  • Adolescence
  • Amygdala
  • Anterior cingulate
  • Depression
  • Development
  • Dorsolateral prefrontal cortex
  • FMRI
  • Limbic system
  • Mood
  • Neuroimaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Depressed mood and lateralized prefrontal activity during a Stroop task in adolescent children. / Killgore, William; Gruber, Staci A.; Yurgelun-Todd, Deborah A.

In: Neuroscience Letters, Vol. 416, No. 1, 06.04.2007, p. 43-48.

Research output: Contribution to journalArticle

Killgore, William ; Gruber, Staci A. ; Yurgelun-Todd, Deborah A. / Depressed mood and lateralized prefrontal activity during a Stroop task in adolescent children. In: Neuroscience Letters. 2007 ; Vol. 416, No. 1. pp. 43-48.
@article{2467375e55b04ebc8488c4f3dce5668f,
title = "Depressed mood and lateralized prefrontal activity during a Stroop task in adolescent children",
abstract = "Negative affective style and depressive disorders share a common pattern of brain activation asymmetry in adults, characterized by reduced left relative to right prefrontal activation. It is not clear whether a similar pattern of asymmetry is related to depressive mood state during the period of adolescence, an important stage of emotional and brain development. We correlated Beck Depression Inventory (BDI) scores from 16 adolescents with prefrontal, anterior cingulate, and amygdala activity during functional magnetic resonance imaging (FMRI) of the Stroop Interference task. Depressed mood correlated positively with activity in the left dorsolateral prefrontal cortex (DLPFC) and anterior cingulate gyrus, and negatively with activity in the right DLPFC. When interpreted from a compensatory recruitment perspective, findings suggest that affective lateralization in adolescents is consistent with that seen in adulthood.",
keywords = "Adolescence, Amygdala, Anterior cingulate, Depression, Development, Dorsolateral prefrontal cortex, FMRI, Limbic system, Mood, Neuroimaging",
author = "William Killgore and Gruber, {Staci A.} and Yurgelun-Todd, {Deborah A.}",
year = "2007",
month = "4",
day = "6",
doi = "10.1016/j.neulet.2007.01.081",
language = "English (US)",
volume = "416",
pages = "43--48",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Depressed mood and lateralized prefrontal activity during a Stroop task in adolescent children

AU - Killgore, William

AU - Gruber, Staci A.

AU - Yurgelun-Todd, Deborah A.

PY - 2007/4/6

Y1 - 2007/4/6

N2 - Negative affective style and depressive disorders share a common pattern of brain activation asymmetry in adults, characterized by reduced left relative to right prefrontal activation. It is not clear whether a similar pattern of asymmetry is related to depressive mood state during the period of adolescence, an important stage of emotional and brain development. We correlated Beck Depression Inventory (BDI) scores from 16 adolescents with prefrontal, anterior cingulate, and amygdala activity during functional magnetic resonance imaging (FMRI) of the Stroop Interference task. Depressed mood correlated positively with activity in the left dorsolateral prefrontal cortex (DLPFC) and anterior cingulate gyrus, and negatively with activity in the right DLPFC. When interpreted from a compensatory recruitment perspective, findings suggest that affective lateralization in adolescents is consistent with that seen in adulthood.

AB - Negative affective style and depressive disorders share a common pattern of brain activation asymmetry in adults, characterized by reduced left relative to right prefrontal activation. It is not clear whether a similar pattern of asymmetry is related to depressive mood state during the period of adolescence, an important stage of emotional and brain development. We correlated Beck Depression Inventory (BDI) scores from 16 adolescents with prefrontal, anterior cingulate, and amygdala activity during functional magnetic resonance imaging (FMRI) of the Stroop Interference task. Depressed mood correlated positively with activity in the left dorsolateral prefrontal cortex (DLPFC) and anterior cingulate gyrus, and negatively with activity in the right DLPFC. When interpreted from a compensatory recruitment perspective, findings suggest that affective lateralization in adolescents is consistent with that seen in adulthood.

KW - Adolescence

KW - Amygdala

KW - Anterior cingulate

KW - Depression

KW - Development

KW - Dorsolateral prefrontal cortex

KW - FMRI

KW - Limbic system

KW - Mood

KW - Neuroimaging

UR - http://www.scopus.com/inward/record.url?scp=33947245584&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947245584&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2007.01.081

DO - 10.1016/j.neulet.2007.01.081

M3 - Article

C2 - 17350756

AN - SCOPUS:33947245584

VL - 416

SP - 43

EP - 48

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -