Depth-sensitive reflectance measurements using obliquely oriented fiber probes

Adrien Wang, Janelle Bender, Joshua Pfefer, Urs Utzinger, Rebekah Drezek

Research output: Contribution to journalConference article

Abstract

Computer simulation was used to facilitate the design of fiber-probe geometries which enable enhanced detection of optical signals arising from specific tissue depths. Obtaining understanding of the relationship between fiber-probe design and tissue interrogation is critical when developing strategies for optical detection of epithelial pre-cancers which originate at known depths from the tissue surface. We investigated how the depth of optical interrogation may be controlled through combinations of collection angles, source-detector separations and numerical apertures. We found that increasing the obliquity of collection fibers at a given source-detector separation can effectively enhance the detection of superficially scattered signals. Fiber numerical aperture provides additional depth selectivity; however, the perturbations in sampling depth achieved through this means are modest relative to the changes generated by modifying the angle of collection and source-detection separation.

Original languageEnglish (US)
Article number10
Pages (from-to)54-65
Number of pages12
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume5691
DOIs
StatePublished - Jul 21 2005
EventOptical Fibers and Sensors for Medical Applications V - San Jose, CA, United States
Duration: Jan 22 2005Jan 25 2005

Keywords

  • Epithelial tissue
  • Fiber-optic probes
  • Monte Carlo
  • Reflectance spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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