Deranged modulatory midbrain opioid and gonadotrophin functions

Relevance to Tourette's Syndrome

R. Sandyk, G. Awerbuch, P. F Regis Kwo-On-Yuen, Colin R Bamford

Research output: Contribution to journalArticle

Abstract

In the following communication we discuss evidence suggesting that an abnormal opioid-gonadotrophin interaction at the midbrain may be essential to the clinical expression of vocal tics in Tourette's Syndrome (TS). Data derived from animal studies and the striking similarity between the symptomatology of TS and encephalitis lethargica (EL) add further support to our hypothesis implicating an abnormal opioid-gonadotrophin interaction in the pathophysiology of TS.

Original languageEnglish (US)
Pages (from-to)95-97
Number of pages3
JournalMedical Hypotheses
Volume36
Issue number1
DOIs
StatePublished - 1991

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Tourette Syndrome
Mesencephalon
Gonadotropins
Opioid Analgesics
Tics
Encephalitis
Communication

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

Cite this

Deranged modulatory midbrain opioid and gonadotrophin functions : Relevance to Tourette's Syndrome. / Sandyk, R.; Awerbuch, G.; Kwo-On-Yuen, P. F Regis; Bamford, Colin R.

In: Medical Hypotheses, Vol. 36, No. 1, 1991, p. 95-97.

Research output: Contribution to journalArticle

Sandyk, R. ; Awerbuch, G. ; Kwo-On-Yuen, P. F Regis ; Bamford, Colin R. / Deranged modulatory midbrain opioid and gonadotrophin functions : Relevance to Tourette's Syndrome. In: Medical Hypotheses. 1991 ; Vol. 36, No. 1. pp. 95-97.
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