Derivation of site-specific skeletal masses within the current ICRP age series

Christopher J Watchman, Deanna Hasenauer, Wesley E. Bolch

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The calculation of absorbed dose to the radiosensitive tissues of the skeleton is routinely performed using reference masses provided in publications from the International Commission on Radiological Protection (ICRP). These values typically include total skeleton tissue masses by reference subject age, but not by individual bone site at a given age. Site-specific variations in absorbed fractions are known to occur for internal alpha-particle and beta-particle emitters, and in certain medical dose reconstructions, site-specific estimates of marrow dose may be desirable. Furthermore, bone-site-specific tissue masses are required to properly estimate skeletal-averaged absorbed fractions and, more importantly, specific absorbed fractions for internalized radionuclides and radiopharmaceuticals. Reference masses by skeletal site are also needed in the development of ICRP compliant tomographic phantoms, as this organ system is initially segmented from medical images only as a homogeneous tissue region. ICRP reference skeletal masses are assigned based upon several independent data sources, many of which may not be entirely consistent with one another. In this study, a methodology is presented, using data from the various ICRP publications, to derive site-specific skeletal tissue masses for each member of the ICRP age series. Active marrow masses are calculated and differences are shown with respect to ICRP Publications 70 and 89 values. New data for a revised surrogate tissue region for the osteoprogenitor cells within bone marrow is presented with estimates of its total mass throughout the skeleton and for different subject ages.

Original languageEnglish (US)
Article number014
Pages (from-to)3133-3150
Number of pages18
JournalPhysics in Medicine and Biology
Volume52
Issue number11
DOIs
StatePublished - Jun 7 2007

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derivation
Tissue
Skeleton
Publications
Bone
musculoskeletal system
Bone Marrow
dosage
Beta Particles
Alpha Particles
bones
Bone and Bones
Alpha particles
estimates
Radiopharmaceuticals
Information Storage and Retrieval
Radioisotopes
Bone Marrow Cells
beta particles
bone marrow

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Derivation of site-specific skeletal masses within the current ICRP age series. / Watchman, Christopher J; Hasenauer, Deanna; Bolch, Wesley E.

In: Physics in Medicine and Biology, Vol. 52, No. 11, 014, 07.06.2007, p. 3133-3150.

Research output: Contribution to journalArticle

Watchman, Christopher J ; Hasenauer, Deanna ; Bolch, Wesley E. / Derivation of site-specific skeletal masses within the current ICRP age series. In: Physics in Medicine and Biology. 2007 ; Vol. 52, No. 11. pp. 3133-3150.
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