Dermorphin sequence with high δ-afinity by fixing the phe sidechain to trans at ξ1

D. Tourwé, K. Verschueren, G. Van Binst, P. Davis, F. Porreca, V. J. Hruby

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The Phe sidechain in dermorphin was fixed into the trans conformation by linking the aromatic ring to the Gly nitrogen through a methylene bridge. The compound has high μ- and δ-opioid activities.

Original languageEnglish (US)
Pages (from-to)1305-1308
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume2
Issue number10
DOIs
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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